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HBS1L Antibody

  • 中文名称：
    HBS1L兔多克隆抗体
  • 货号：
    CSB-PA010160GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y450
  • 基因名：
    HBS1L
  • 别名：
    EF 1a antibody; ERF3 similar protein antibody; ERFS antibody; HBS1 antibody; HBS1 like antibody; HBS1 like protein antibody; HBS1, S. cerevisiae, homolog of antibody; HBS1-like (S. cerevisiae) antibody; HBS1-like protein antibody; Hbs1l antibody; HBS1L_HUMAN antibody; Hsp70 subfamily B suppressor 1 like protein antibody; HSPC276 antibody; KIAA1038 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HBS1L
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway.; Facilitates the association of the exosome complex with the SKI complex.
  • 基因功能参考文献：
    1. Identification of HBS1LV3, a short splicing isoform of HBS1L, as a linker between the human cytoplasmic exosome and the SKI complex. PMID: 28204585
    2. genome-wide association analyses identified a new genome-wide significant locus on the HBS1L-MYB intergenic region for platelet-to-lymphocyte ratio PMID: 29066854
    3. Studied association of BCL11A single nucleotide polymorphisms(snps) and HBS1L-MYB Intergenic snps with Hereditary Persistence of Fetal Hemoglobin (HPFH) in a cohort of sickle cell patients. PMID: 28332727
    4. Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development. PMID: 27681415
    5. Knowledge of the interacting residues in the yeast complexes allowed identification of a splice variant of human HBS1-Like as a Ski7-like exosome-binding protein, revealing the evolutionary conservation of this cytoplasmic cofactor. PMID: 27345150
    6. high-risk genotypes of six Hb F-associated SNPs, rs9376090, rs7776054, rs9399137, rs9389268, rs9402685 in the HBS1L-MYB intergenic region and rs189984760 in the BCL11A locus, showed association with high Hb F levels PMID: 28361591
    7. The HBS1L-MYB region contains two HbF QTLs, HMIP-2A and HMIP-2B (HBS1L-MYB intergenic polymorphisms A and B) HMIP-A is tagged by the SNP rs9399137, with the C" allele promoting HbF. Only 1 sickle cell patient had this allele. HMIP-B was tagged in these patients by rs4895441and represented Amerindian ethnic origin. PMID: 26849705
    8. we find that the interaction of UPF2 with UPF3b interferes with the assembly of the UPF2-eRF3 complex, and that UPF2 binds UPF3b more strongly than eRF3 PMID: 26740584
    9. eRF3 neither interacts with the rRNA ribosephosphate backbone nor dissociates from the complex after GTP hydrolysis at translation termination. PMID: 26655225
    10. The study compares polymorphism at BCL11A to HBS1L-MYB loci and explains less of the variance in HbF in patients with sickle cell disease in Cameroon. PMID: 25488618
    11. Genetic variants of HBS1L is associated with sickle cell disease. PMID: 24667352
    12. Several HBS1L-MYB intergenic variants reduce transcription factor binding, affecting interactions with MYB and MYB expression levels. This may explain the genetic association of HBS1L-MYB intergenic polymorphisms with erythroid traits and HbF levels. PMID: 24614105
    13. The non-stop decay mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski complex. PMID: 23667253
    14. Studies indicate that single nucleotide polymorphisms (SNPs) in regions of BCL11A and HBS1L-MYB intergenic polymorphism are the major modifiers of HbF in African Americans. PMID: 22936743
    15. A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression. PMID: 21385855
    16. Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1. PMID: 21448132
    17. crystal structures of the MLLE domain from PABPC1 in complex with the two PAM2 regions of eRF3 PMID: 20418951
    18. SNPs in BCL11A and the HBS1L-MYB region did not show statistically significant correlations with HbFlevels.This suggests that the BCL11A and HBS1L-MYB loci have a minor effect on HbF level compared to the XmnI QTL in beta-thalassemia intermedia patients. PMID: 20472475
    19. HBS1L-related genetic variants play a key role in control of fetal hemoglobin levels. PMID: 17592125
    20. The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts. PMID: 17712044
    21. Association of SNP in exon 1 of HBS1L with hemoglobin F level in beta0-thalassemia/hemoglobin E. PMID: 18839276

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  • 亚细胞定位：
    [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family
  • 组织特异性：
    Detected in heart, brain, placenta, liver, muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 4834

    OMIM: 612450

    KEGG: hsa:10767

    STRING: 9606.ENSP00000356811

    UniGene: Hs.378532