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GSPT2 Antibody

  • 中文名称：
    GSPT2多克隆抗体
  • 货号：
    CSB-PA009967GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8IYD1
  • 基因名：
    GSPT2
  • 别名：
    eRF3b antibody; ERF3B_HUMAN antibody; Eukaryotic peptide chain release factor GTP-binding subunit ERF3B antibody; Eukaryotic peptide chain release factor subunit 3b antibody; G1 to S phase transition 2 antibody; G1 to S phase transition protein 2 homolog antibody; Gspt2 antibody; GST2 antibody; peptide chain release factor 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GSPT2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
  • 基因功能参考文献：
    1. Loss of GSPT2 and/or MAGED1 function may contribute to the intellectual disability. PMID: 28414775
    2. The survivin and eRF3 complex may function in spindle formation and segregation of chromosomes and cytokinesis. PMID: 23377885
    3. The tumor marker eRF3B can change the cell cycle and influence the phosphorylation status of 4E-BP1. PMID: 24466059
    4. The proteolytic cleavage of eRF3a and eRF3b into p-eRF3 leads to release an amino-terminal fragment containing nuclear export signal to allow the relocalization of eRF3 into the nucleus to interact with the p14ARF. PMID: 24569073
    5. eRF3b can substitute for eRF3a in its translation termination function. PMID: 15987998
    6. eRF1's M domain contacts eRF3's GTPase domain PMID: 19417105

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, ERF3 subfamily
  • 组织特异性：
    Highly expressed in IUCC stage II colorectal cancer (CRC).
  • 数据库链接：

    HGNC: 4622

    OMIM: 300418

    KEGG: hsa:23708

    STRING: 9606.ENSP00000341247

    UniGene: Hs.59523