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GEM Antibody

  • 中文名称：
    GEM兔多克隆抗体
  • 货号：
    CSB-PA009362ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA009362ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA009362ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GEM Polyclonal antibody
  • Uniprot No.：
    P55040
  • 基因名：
    GEM
  • 别名：
    GEM antibody; KIRGTP-binding protein GEM antibody; GTP-binding mitogen-induced T-cell protein antibody; RAS-like protein KIR antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human GTP-binding protein GEM protein (1-150AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.
  • 基因功能参考文献：
    1. Down regulation of Gem expression was involved in the pathogenesis of hepatocellular carcinoma (HCC), and it might be a favorable independent prognostic parameter for HCC. PMID: 25155751
    2. These findings demonstrate a new role of Gem/Gmip/RhoA signaling in cortical actin regulation during early mitotic stages. PMID: 25173885
    3. Gem is involved both in T-cell spontaneous cell migration as well as chemotaxis and plays an important role in cell-to-cell HTLV-1 viral transmission. PMID: 24586148
    4. Data show a mechanism by which GTPase Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9. PMID: 22964304
    5. Gem contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2+) channels. PMID: 22589533
    6. GEM plays a key role during C. pneumoniae entry into human cells. PMID: 20233927
    7. We discuss the structural and functional properties of RGK proteins and highlight recent work addressing the mechanism of Gem regulation by calmodulin and 14-3-3. PMID: 16242932
    8. crystallographic structure and biochemical characterization indicate that Gem G-domain markedly prefers GDP over GTP PMID: 17052716
    9. Gem is a bona fide GTPase that exhibits striking structural and biochemical features that should impact its regulation and cellular activities PMID: 17107948

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, RGK family
  • 组织特异性：
    Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.
  • 数据库链接：

    HGNC: 4234

    OMIM: 600164

    KEGG: hsa:2669

    STRING: 9606.ENSP00000297596

    UniGene: Hs.654463