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GALNT14 Antibody

  • 中文名称：
    GALNT14兔多克隆抗体
  • 货号：
    CSB-PA836212LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: GALNT14 antibody at 2µg/ml
      Lane 1: Rat gonad tissue
      Lane 2: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 65, 61, 62 kDa
      Observed band size: 65 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA836212LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GALNT14 Polyclonal antibody
  • Uniprot No.：
    Q96FL9
  • 基因名：
    GALNT14
  • 别名：
    GalNAc T14 antibody; GalNAc-T14 antibody; Galnt14 antibody; GLT14_HUMAN antibody; Polypeptide GalNAc transferase 14 antibody; Polypeptide N acetylgalactosaminyltransferase 14 antibody; Polypeptide N-acetylgalactosaminyltransferase 14 antibody; pp GaNTase 14 antibody; pp-GaNTase 14 antibody; Protein UDP acetylgalactosaminyltransferase 14 antibody; Protein-UDP acetylgalactosaminyltransferase 14 antibody; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 14 antibody; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 14 protein (1-552AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GALNT14 Antibody (CSB-PA836212LA01HU)，的标记方式是Non-conjugated。对于GALNT14 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836212LB01HU GALNT14 Antibody, HRP conjugated ELISA
    FITC CSB-PA836212LC01HU GALNT14 Antibody, FITC conjugated
    Biotin CSB-PA836212LD01HU GALNT14 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
  • 基因功能参考文献：
    1. Silencing of GALNT14 in osterix-overexpressed cells restored the decreased chemosensitivity. Conversely, overexpression of GALNT14 in osterix-knockdown cells abrogated the increased chemosensitivity in breast cancer cells. PMID: 29227978
    2. The analysis showed that the "TT" genotype was associated with unfavorable overall survival (OS, P = 0.009). PMID: 27124048
    3. miR-125a functions as tumor suppressor in ovarian cancer by targeting GALNT14. PMID: 27133078
    4. GALNT14 genotypes were significantly associated with clinical outcomes of transcatheter arterial chemoembolization. PMID: 26871639
    5. Expression of GalNAc-T14 or HOXB9 was strongly correlated with reduced recurrence-free survival in lung adenocarcinomas. PMID: 26544896
    6. Recurrence of mutation suggests GALNT14 as a novel gene potentially involved in neuroblastoma predisposition. PMID: 26309160
    7. GALNT14 stimulates MMP-2 expression. PMID: 24962947
    8. GALN14 genotype (rs9679162) was an effective predictor for therapeutic outcome in advanced hepatocellular carcinoma (HCC) patients treated by FMP chemotherapy. PMID: 23959947
    9. Studies demonstrate that IGFBP-3 and GalNAc-T14 are colocalized in MCF-7 cells, and confirmed the interaction between IGFBP-3 and GalNAc-T14; these results reveal a minimal region of GalNAc-T14 that was sufficiently bound to the full-length IGFBP-3. PMID: 22441125
    10. Results provide evidence that GalNAc-T14 may be a potential biomarker for breast cancer by immunohistochemistry. PMID: 20356418
    11. GALNT14 and FUT3/6 H-scores were significantly higher in non-small cell lung cancer cell lines sensitive to dulanermin and drozitumab versus resistant cell lines PMID: 20179215
    12. cloning and characterization; results provide evidence that pp-GalNAc-T14 is a new member of the pp-GalNAc-T family and suggest that it may be involved in the O-glycosylation in kidney PMID: 12507512
    13. The role of GalNAc-T14 as an intracellular mediator of the effects of IGFBP-3 need to be verified in future studies. PMID: 17434446
    14. GALNT14 may be involved in regulating the apoptotic action of IGFBP-3. PMID: 19805900

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 2 family, GalNAc-T subfamily
  • 组织特异性：
    Detected in renal tubules (at protein level). Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bl
  • 数据库链接：

    HGNC: 22946

    OMIM: 608225

    KEGG: hsa:79623

    STRING: 9606.ENSP00000288988

    UniGene: Hs.468058