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DDT Antibody

  • 中文名称：
    DDT兔多克隆抗体
  • 货号：
    CSB-PA221047
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human-placenta, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-placenta, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    P30046
  • 基因名：
    DDT
  • 别名：
    D dopachrome decarboxylase antibody; D dopachrome tautomerase antibody; D-dopachrome decarboxylase antibody; D-dopachrome tautomerase antibody; DDCT antibody; Ddt antibody; DOPD_HUMAN antibody; Phenylpyruvate tautomerase II antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 50-90
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
  • 基因功能参考文献：
    1. D-dopachrome tautomerase transcription may be regulated in a cell-dependent manner, and was enhanced by AMPK activation in SGBS adipocytes through inhibiting the mTOR signaling PMID: 28445821
    2. The knockdown of D-DT and MIF, individually and additively, inhibited the proliferation, migration, and invasion in HeLa and SiHa cells and restrained the growth of xenograft tumor. PMID: 28338494
    3. These results have implications for the manner in which D-DT and MIF compete with each other for binding to the CD74 receptor and for the relative potency of DRa1-MOG-35-55 and RTL1000 for competitive inhibition of D-DT and MIF binding and activation through CD74. PMID: 27573366
    4. Study demonstrated that DDT was over- expressed in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines in a pattern correlated with MIF, and knockdown of DDT and MIF in PANC- 1 cells cooperatively inhibited cell proliferation, invasion and tumor formation. The tautomerase activities of both MIF and DDT are required for their negative regulatory role in p53 and their tumor-promoting functions. PMID: 27434219
    5. DDT was increased in burn patients. PMID: 27209369
    6. Gene expression level of DDT is significantly higher in AD patients when compared to normal controls. PMID: 26943237
    7. High MIF-2 levels are predictive of the development of organ dysfunction in myocardial ischemia reperfusion injury. PMID: 26234719
    8. Both p53 wildtype and mutant human lung adenocarcinoma tumors rely on MIF family members for maximal cell growth and survival. PMID: 24932684
    9. findings identify DDT as a functionally redundant but more potent cytokine to MIF in cancer and suggest that current attempts to inhibit MIF signaling may fail because of DDT compensation. PMID: 24356968
    10. D-dopachrome tautomerase secreted from adipocytes acts on preadipocytes to promote IL-6 expression and to inhibit adipogenesis by suppressing the induction of genes encoding adipogenic regulators PMID: 22951300
    11. DDT acts on adipocytes to regulate lipid metabolism through AMPK and/or PKA pathway(s) and improves glucose intolerance caused by obesity. PMID: 22428043
    12. These data indicate that D-DT is a MIF-like cytokine. PMID: 21817065
    13. D-DT-dependent beta-catenin stabilization is regulated by COX-2 expression, suggesting the existence of an amplification loop between COX-2- and beta-catenin-mediated transcription in these cells PMID: 21071513
    14. role of tautomerase active site of macrophage migration inhibitory factor as a potential target for discovery of novel anti-inflammatory agents PMID: 11997397
    15. DDT is for the first time demonstrated in the skin and can be related to inflammation, and its covariation with MIF strengthens this observation. PMID: 12823441
    16. D-dopachrome tautomerase (D-DT) and macrophage migration inhibitory factor, individually and additively, promote vascular endothelial growth factor and CXCL8 expression in human lung adenocarcinoma cell lines. PMID: 18684922

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    MIF family
  • 数据库链接：

    HGNC: 2732

    OMIM: 602750

    KEGG: hsa:1652

    STRING: 9606.ENSP00000215773

    UniGene: Hs.656723