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CHAC2 Antibody

  • 中文名称：
    CHAC2兔多克隆抗体
  • 货号：
    CSB-PA005309GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8WUX2
  • 基因名：
    CHAC2
  • 别名：
    Cation transport regulator like protein 2 antibody; Cation transport regulator-like protein 2 antibody; ChaC; cation transport regulator homolog 2 (E. coli) antibody; chac2 antibody; CHAC2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CHAC2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
  • 基因功能参考文献：
    1. The data revealed that CHAC2 prevented CHAC1-mediated GSH degradation, which suggests that CHAC2 competes with CHAC1 to maintain GSH homeostasis. PMID: 29054545
    2. Results showed for the first time that CHAC2 was degraded by the ubiquitin-proteasome pathway and CHAC2 expression inhibited tumor cell growth, proliferation, migration in vitro and in vivo. Mechanistic study showed that CHAC2 induced mitochondrial apoptosis and autophagy through unfolded protein response. PMID: 28837156
    3. Human and mouse ChaC2 proteins purified in vitro show 10-20-fold lower catalytic efficiency than ChaC1, although they showed comparable Km values PMID: 27913623
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Gamma-glutamylcyclotransferase family, ChaC subfamily
  • 数据库链接：

    HGNC: 32363

    OMIM: 617446

    KEGG: hsa:494143

    STRING: 9606.ENSP00000295304

    UniGene: Hs.585944