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BCL7A Antibody

  • 中文名称：
    BCL7A兔多克隆抗体
  • 货号：
    CSB-PA040224
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q4VC05
  • 基因名：
    BCL7A
  • 别名：
    B cell CLL/lymphoma 7 antibody; B cell CLL/lymphoma 7 protein family member A antibody; B cell CLL/lymphoma 7A antibody; B-cell CLL/lymphoma 7 protein family member A antibody; BCL 7 antibody; BCL7 antibody; bcl7a antibody; BCL7A_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Bcl-7a.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. BCL7A, BRWD3, and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations. PMID: 29166413
    2. Data suggest that BCL7A may play an important role in cutaneous T-cell lymphoma (CTCL) carcinogenesis. PMID: 22856870
    3. Report describes BCL7A protein expression in normal lymphoid tissues and lymphomas using immunohistochemistry. PMID: 23043359
    4. Promoter hypermethylation of BCL7a is associated with cutaneous T-cell lymphoma PMID: 15897551
    5. deletion of genes BCL7A in early-stage mycosis fungoides. PMID: 18663754
    6. Variants in BCL7A were strongly related to diffuse large B-cell lymphoma. PMID: 19336552

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  • 相关疾病：
    Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.
  • 蛋白家族：
    BCL7 family
  • 数据库链接：

    HGNC: 1004

    OMIM: 601406

    KEGG: hsa:605

    UniGene: Hs.530970