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ADH7 Antibody

  • 中文名称：
    ADH7兔多克隆抗体
  • 货号：
    CSB-PA001362LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ADH7 antibody at 2µg/ml + Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 42, 43 kDa
      Observed band size: 42 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA001362LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA001362LA01HU at dilution of 1:100
    • Immunofluorescence staining of HepG2 cells with CSB-PA001362LA01HU at 1:133,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
  • 其他：

产品详情

  • 产品描述：

    The ADH7 antibody is a polyclonal antibody that is generated in rabbits by immunizing with recombinant human Alcohol dehydrogenase class 4 mu/sigma chain protein (1-386aa). The primary function of the ADH7 polyclonal antibody is to recognize and bind to the ADH7 protein in samples from both human and mouse species.

    The ADH7 antibody is protein G purified, with a purity greater than 95%, which ensures its high quality and reliability. This antibody has been tested for use in a range of applications, including ELISA, WB, IHC, and IF. Its availability in different applications allows for the investigation of the expression and localization of ADH7 in different tissues and cells in human and mouse samples.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ADH7 Polyclonal antibody
  • Uniprot No.：
    P40394
  • 基因名：
    ADH7
  • 别名：
    ADH7 antibody; All-trans-retinol dehydrogenase [NAD(+)] ADH7 antibody; EC 1.1.1.105 antibody; Alcohol dehydrogenase class 4 mu/sigma chain antibody; EC 1.1.1.1 antibody; Alcohol dehydrogenase class IV mu/sigma chain antibody; Gastric alcohol dehydrogenase antibody; Omega-hydroxydecanoate dehydrogenase ADH7 antibody; EC 1.1.1.66 antibody; Retinol dehydrogenase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Alcohol dehydrogenase class 4 mu/sigma chain protein (1-386AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ADH7 Antibody (CSB-PA001362LA01HU)，的标记方式是Non-conjugated。对于ADH7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001362LB01HU ADH7 Antibody, HRP conjugated ELISA
    FITC CSB-PA001362LC01HU ADH7 Antibody, FITC conjugated
    Biotin CSB-PA001362LD01HU ADH7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation.
  • 基因功能参考文献：
    1. These results suggest that variants near ADH7 may play a role in protection from alcohol dependence in this Mexican American cohort. PMID: 25527893
    2. Transcriptional regulatory elements of ADH7 were identified that effect gene expression. PMID: 24512552
    3. common ADH1-7 variants conferred risk for both schizophrenia in African-Americans and autism in European-Americans. PMID: 23468174
    4. The rs1573496 (ADH7) polymorphism was not associated with colorectal cancer risk overall in Western-European populations. However, the relationship between alcohol and colorectal cancer risk might be modulated by the rs1573496 (ADH7) polymorphism. PMID: 23149980
    5. The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non-Hispanic white populations. PMID: 20336794
    6. An association between age at onset of regular alcohol use and a SNP just upstream of ADH7 (rs2654849, p = .003) was observed. PMID: 20158305
    7. ADH7 gene polymorphisms are associated with upper aerodigestive tract cancers. PMID: 19861527
    8. the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared. PMID: 17918242
    9. A recombinational hotspot within intron 7 of the ADH7 gene were seen using 25 SNPs; haplotypes associated with inter-individual variation in the early stages of alcohol metabolism were identified. PMID: 17921519
    10. Changes in the activity of class IV ADH in the sera of patients with gastric cancer seems to be caused by release of the isoenzyme from cancer cells. PMID: 18231859
    11. Single Nucleotide Polymorphism in ADH7 gene is associated with upper aerodigestive cancer. PMID: 18500343

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Zinc-containing alcohol dehydrogenase family, Class-IV subfamily
  • 组织特异性：
    Preferentially expressed in stomach.
  • 数据库链接：

    HGNC: 256

    OMIM: 600086

    KEGG: hsa:131

    STRING: 9606.ENSP00000420269

    UniGene: Hs.389