fgfr3
FGFR3，即成纤维细胞生长因子受体3，别名FGFR3b、CD333等。FGFR3是一种跨膜受体酪氨酸激酶，属于FGFR家族成员之一，由人体细胞自身的基因编码。其作用机制主要是通过与成纤维细胞生长因子(FGF)结合，促使FGFR3发生二聚化和自磷酸化，进而激活下游的信号传导途径。FGFR3的激活可以促进细胞增殖、分化、迁移和存活，对组织再生和肿瘤发展等生物学过程具有重要影响。FGFR3在生物学上的意义非常广泛，它参与调节多种细胞行为和生理过程。FGFR3信号通路的激活可以促进细胞周期进程，抑制细胞凋亡，从而有助于维持肿瘤细胞的生存。此外，FGFR3还与肿瘤的侵袭、转移和血管生成等恶性行为密切相关。在肿瘤治疗中，FGFR3已成为一个重要的分子靶点，针对FGFR3的抑制剂正在被开发用于治疗某些类型的癌症，如膀胱癌等。FGFR3的功能异常与多种疾病有关，包括某些遗传性骨骼疾病和肿瘤，因此，深入研究FGFR3的生物学角色对于理解相关疾病的发病机制和开发新的治疗方法具有重要意义。
热销产品
Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (CSB-YP008646HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP008646HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) FGFR3.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP008646HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) FGFR3.
FGFR3 Recombinant Monoclonal Antibody (CSB-RA008646MA1HU)
验证数据
Overlay Peak curve showing MCF7 cells stained with CSB-RA008646MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human Fibroblast growth factor receptor 3(FGFR3) ELISA kit (CSB-EL008646HU)
验证数据
货号：CSB-EL008646HU
规格：96T/48T
灵敏度：15.6 pg/mL
检测范围：62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
fgfr3 Antibodies
fgfr3 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA008646LA01HU | FGFR3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA008646LC01HU | FGFR3 Antibody, FITC conjugated | Human | |
| CSB-PA008646LD01HU | FGFR3 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA164777 | FGFR3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA008248 | FGFR3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA114336 | FGFR3 Antibody | Human,Mouse | ELISA,IHC |
| CSB-RA555849A0HU | FGFR3 Recombinant Monoclonal Antibody | Human | ELISA, IF |
| CSB-RA966627A0HU | FGFR3 Recombinant Monoclonal Antibody | Human | ELISA, WB |
| CSB-RA008646MA1HU | FGFR3 Recombinant Monoclonal Antibody | Human | ELISA, FC |
fgfr3 Proteins
fgfr3 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008646CH1 CSB-EP008646CH1 CSB-BP008646CH1 CSB-MP008646CH1 CSB-EP008646CH1-B |
Recombinant Chicken Fibroblast growth factor receptor 3 (FGFR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008646CH | Recombinant Chicken Fibroblast growth factor receptor 3 (FGFR3) | in vitro E.coli expression system |
fgfr3 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008646HU | Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial | Yeast |
| CSB-EP008646HU | Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial | E.coli |
| CSB-YP008646HU(A4) | Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial | Yeast |
| CSB-BP008646HU CSB-MP008646HU CSB-EP008646HU-B |
Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP008646HU(A4) | Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial | E.coli |
| CSB-BP008646HU(A4) CSB-MP008646HU(A4) CSB-EP008646HU(A4)-B |
Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP003871HU | Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active) | Mammalian cell |
fgfr3 Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008646XBE CSB-EP008646XBE CSB-BP008646XBE CSB-MP008646XBE CSB-EP008646XBE-B |
Recombinant Xenopus laevis Fibroblast growth factor receptor 3 (fgfr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
fgfr3 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008646MO CSB-EP008646MO CSB-BP008646MO CSB-MP008646MO CSB-EP008646MO-B |
Recombinant Mouse Fibroblast growth factor receptor 3 (Fgfr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
fgfr3 Proteins for Pleurodeles waltl (Iberian ribbed newt)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008646EWZ CSB-EP008646EWZ CSB-BP008646EWZ CSB-MP008646EWZ CSB-EP008646EWZ-B |
Recombinant Pleurodeles waltl Fibroblast growth factor receptor 3 (FGFR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
fgfr3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008646DIL CSB-EP008646DIL CSB-BP008646DIL CSB-MP008646DIL CSB-EP008646DIL-B |
Recombinant Danio rerio Fibroblast growth factor receptor 3 (fgfr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
fgfr3 ELISA Kit
fgfr3 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL008646HU | Human Fibroblast growth factor receptor 3(FGFR3) ELISA kit | serum, plasma, tissue homogenates | 15.6 pg/mL |
