Tyms
TYMS(胸苷酸合成酶)是DNA合成过程中的关键酶,由两个相同亚单位组成的二聚体蛋白,位于第18号染色体上。其主要功能是将脱氧尿嘧啶核苷酸(dUMP)与五氢叶酸(FH4)催化成脱氧胸腺嘧啶核苷酸(dTMP),这一反应对于细胞DNA复制和修复至关重要。TYMS在细胞生长和增殖中起到核心作用,其表达水平在肿瘤细胞中通常较高,与肿瘤细胞的增殖、浸润和转移密切相关。因此,TYMS成为抗肿瘤药物的重要靶点,如5-氟尿嘧啶(5-FU)等化疗药物通过抑制TYMS活性来阻止DNA合成,从而抑制肿瘤细胞生长。TYMS的研究不仅有助于理解细胞生物学过程,还为抗肿瘤药物的研发提供了新途径。
热销产品
TYMS Recombinant Monoclonal Antibody (CSB-RA584889A0HU)
验证数据
Western Blot
Positive WB detected in: Hela whole cell lysate, 293T whole cell lysate, 293 whole cell lysate, Jurkat whole cell lysate, HepG2 whole cell lysate, HL-60 whole cell lysate
All lanes: Thymidylate Synthase antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 36, 32, 27 kDa
Observed band size: 36 kDa
Tyms Antibodies
Tyms for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA025393GA01HU | TYMS Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA025393LA01HU | TYMS Antibody | Human | ELISA, WB, IF, IP |
CSB-PA025393LB01HU | TYMS Antibody, HRP conjugated | Human | ELISA |
CSB-PA025393LC01HU | TYMS Antibody, FITC conjugated | Human | |
CSB-PA025393LD01HU | TYMS Antibody, Biotin conjugated | Human | ELISA |
CSB-RA584889A0HU | TYMS Recombinant Monoclonal Antibody | Human | ELISA, WB |
Tyms Proteins
Tyms Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP025393HU CSB-EP025393HU CSB-BP025393HU CSB-MP025393HU CSB-EP025393HU-B |
Recombinant Human Thymidylate synthase (TYMS) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Tyms ELISA Kit
Tyms ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-E10815h | Human thymidylate synthetase,TS ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.078 ng/mL |