Ifna2
IFNA2(干扰素-α2)是干扰素-α(IFN-α)家族成员之一,具有抗病毒、抗肿瘤和免疫调节功能。它是一种由约165-166个氨基酸残基组成的蛋白质,分子量约18-21 kDa,具有α-螺旋和β-折叠结构域。IFNA2基因位于人类染色体9上,与其他IFN-α亚型基因聚集。其主要功能包括激活细胞内抗病毒防御机制、抑制肿瘤细胞增殖、促进肿瘤细胞凋亡以及增强免疫细胞活性。IFNA2通过与其受体结合,激活JAK-STAT信号通路,进而磷酸化STAT蛋白,导致它们二聚化并转移到细胞核中,调控干扰素刺激基因(ISGs)的表达。此外,IFNA2还涉及PI3K-AKT和MAPK信号通路,参与细胞生存、增殖、分化和凋亡等过程。临床上,IFNA2被用于治疗乙型和丙型肝炎以及某些类型的癌症,尽管治疗效果可能受到个体差异、病毒抗性和副作用的影响。
热销产品
Recombinant Human Interferon alpha-2 (IFNA2) (CSB-EP360706HUe3)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Ifna2 Antibodies
Ifna2 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA06504D0Rb | IFNA2 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA06504B0Rb | IFNA2 Antibody, HRP conjugated | Human | ELISA |
CSB-PA06504A0Rb | IFNA2 Antibody | Human, Mouse, Rat | ELISA,WB ,IHC |
CSB-PA250552 | IFNA2 Antibody | Human | ELISA,IHC |
CSB-PA048892 | IFNA2 Antibody | Human | ELISA,IHC |
Ifna2 Proteins
Ifna2 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP360706HU | Recombinant Human Interferon alpha-2 (IFNA2) | Yeast |
CSB-EP360706HU | Recombinant Human Interferon alpha-2 (IFNA2) | E.coli |
CSB-AP002761HU | Recombinant Human Interferon alpha-2 protein (IFNA2) | Yeast |
CSB-AP002771HU | Recombinant Human Interferon alpha-2 protein (IFNA2), partial (Active) | E.Coli |
CSB-AP002781HU | Recombinant Human Interferon alpha-2 protein (IFNA2) | Yeast |
CSB-BP360706HU CSB-EP360706HU-B |
Recombinant Human Interferon alpha-2 (IFNA2) | Baculovirus In Vivo Biotinylation in E.coli |
CSB-AP004191HU | Recombinant Human Interferon alpha-2 (IFNA2) (Active) | E.coli |
CSB-EP360706HUe3 | Recombinant Human Interferon alpha-2 (IFNA2) | E.coli |
Ifna2 Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-EP365593MO CSB-BP365593MO CSB-EP365593MO-B |
Recombinant Mouse Interferon alpha-2 (Ifna2) | E.coli Baculovirus In Vivo Biotinylation in E.coli |
Ifna2 ELISA Kit
Ifna2 ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL011038HU | Human interferon alpha-2(IFNA2) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 7.8 pg/ml. |
Ifna2 ELISA Kit for Mus musculus (Mouse)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL011038MO | Mouse interferon alpha-2(IFNA2) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 2.35 pg/mL |