Cxcr5
CXCR5，即C-X-C基序趋化因子受体5，别名CD185。它是一种G蛋白偶联受体，属于趋化因子受体家族成员，主要在B细胞、滤泡辅助性T细胞（Tfh）、一些T细胞亚群和一些树突状细胞上表达。CXCR5的作用机制是通过与特定的配体CXCL13结合，这种结合激活了受体，进而触发细胞内信号传导，如通过Gαi蛋白激活PI3K、AKT和ERK/MAPK等信号通路，导致细胞的迁移、增殖和分化。CXCR5在生物学上的意义主要体现在其对B细胞和Tfh细胞的迁移和定位的调控作用。在次级淋巴器官如淋巴结和脾脏中，CXCR5与其配体CXCL13的相互作用对于形成B细胞滤泡和Tfh细胞区至关重要，这对于适应性免疫反应的发生和维持至关重要。此外，CXCR5也在某些自身免疫性疾病、炎症性疾病和肿瘤中发挥作用，其表达水平的变化可能与疾病的进展相关。因此，CXCR5是免疫学研究和相关疾病治疗中的一个潜在靶点。
热销产品
Recombinant Human C-X-C chemokine receptor type 5 (CXCR5), partial (CSB-YP006255HU1a4)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CXCR5 Antibody (CSB-PA006255LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA006255LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA006255LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA006255LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Cxcr5 Antibodies
Cxcr5 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA006273 | CXCR5 Antibody | Human | WB, ELISA |
| CSB-PA158258 | CXCR5 Antibody | Human | ELISA,IHC |
| CSB-PA006255LA01HU | CXCR5 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006255LD01HU | CXCR5 Antibody, Biotin conjugated | Human | ELISA |
Cxcr5 Proteins
Cxcr5 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006255RA1 CSB-EP006255RA1 CSB-BP006255RA1 CSB-MP006255RA1 CSB-EP006255RA1-B |
Recombinant Rat C-X-C chemokine receptor type 5 (Cxcr5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006255RA | Recombinant Rat C-X-C chemokine receptor type 5 (Cxcr5) | in vitro E.coli expression system |
Cxcr5 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-EP006255HU1 CSB-BP006255HU1 CSB-MP006255HU1 CSB-EP006255HU1-B |
Recombinant Human C-X-C chemokine receptor type 5 (CXCR5), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006255HU | Recombinant Human C-X-C chemokine receptor type 5 (CXCR5) | in vitro E.coli expression system |
| CSB-YP006255HU1 | Recombinant Human C-X-C chemokine receptor type 5 (CXCR5), partial | Yeast |
| CSB-YP006255HU1b0 | Recombinant Human C-X-C chemokine receptor type 5 (CXCR5), partial | Yeast |
| CSB-YP006255HU1a4 | Recombinant Human C-X-C chemokine receptor type 5 (CXCR5), partial | Yeast |
