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  4. Recombinant Human Ras-related protein Rab-18 (RAB18)

Recombinant Human Ras-related protein Rab-18 (RAB18)

  • 中文名称：
    人RAB18重组蛋白
  • 货号：
    CSB-EP878835HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    AA959686; RAB18; RAB18 small GTPase; RAB18; member RAS oncogene family; RAB18_HUMAN; RAB18LI1; Ras related protein Rab 18; Ras-asssociated protein RAB18; Ras-related protein Rab-18; RP11-148B2.1; WARBM3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    49.7kDa
  • 表达区域：
    1-206aa
  • 氨基酸序列
    MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLSHREEGQGGGACGGYC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal GST-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.
  • 基因功能参考文献：
    1. The s found that the previously documented interaction between TRAPPII and COPI was also required for the recruitment of Rab18 to the lipid droplet. PMID: 28003315
    2. findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people. PMID: 24996981
    3. RAB18 is the direct target of miR-455-5p in gastric cancer. PMID: 27451075
    4. Warburg Micro syndrome is caused by RAB18 deficiency. PMID: 26063829
    5. These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets. PMID: 24997429
    6. High RAB18 expression is associated with glioma. PMID: 24477653
    7. Rab18-mediated membrane trafficking of FASN and NS3 facilitates dengue virus replication. PMID: 24696471
    8. Rab18 interacts with the HCV nonstructural protein NS5A. PMID: 23935497
    9. Hepatitis B virus X protein enhances proliferation of hepatoma cells through Rab18. PMID: 23471881
    10. Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2. [Review] PMID: 23176487
    11. performed autozygosity mapping in five consanguineous families with Warburg micro syndrome without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18 PMID: 21473985
    12. Rab18 regulates lipid droplet-associated membrane formation PMID: 15914536
    13. analysis of a novel splice variant of human Rab18 gene PMID: 16147880
    14. Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion. PMID: 18349058
    15. Rab18 and Rab43 have key roles in ER-Golgi trafficking. PMID: 18664496
    16. Rab18 is recruited to lipid droplets during lipolysis PMID: 16207721

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  • 相关疾病：
    Warburg micro syndrome 3 (WARBM3)
  • 亚细胞定位：
    Apical cell membrane. Lipid droplet.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 14244

    OMIM: 602207

    KEGG: hsa:22931

    STRING: 9606.ENSP00000349415

    UniGene: Hs.406799