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Recombinant Xenopus laevis Cannabinoid receptor 1 (cnr1)

  • 中文名称：
    Recombinant Xenopus laevis Cannabinoid receptor 1(cnr1)
  • 货号：
    CSB-CF770415XBE
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    cnr1; Cannabinoid receptor 1; CB-R; CB1
  • 种属：
    Xenopus laevis (African clawed frog)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-470
  • 氨基酸序列
    MKSILDGLADTTFRTITTDLLYLGPNEVQYDDSKGDISSKLVYFPQKLPLSSLRGDPLHE KMTIIDDPLLSIPLDQINATDFYNKSIIFKDTDDNVQCGKNFMDMECFMILTPSQQLVIA ALSIILGTFTVLENMLVLVVIVQSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVF HRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPMSYKRIVTRTKAVIAFCMM WTIAIVIAVLPLFGWNCIKLRSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWK AHNHAVRMLQRGTQKSIIVHTSEDGKVHITRPDQTRMDIRLAKTLVLILVVLIICWGPLM AIMVYDVFGKINKTIKTVFAFCSVLCLLNSTVNPIIYALRSKDLRNAFCSMFPSCQGTAQ PLDNSMESDCQNRHVNNSNAHRAAESCIKSTVKIAKVTMSVSTDTSAEAV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for cannabinoids. Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues. Regulates cellular respiration and energy production in response to cannabinoids. Signaling typically involves reduction in cyclic AMP. May be involved in the control of reproductive function.
  • 基因功能参考文献：
    1. A novel mechanism has been identified underlying a CB1R-mediated increase in retinal ganglion cell intrinsic excitability acting through AMPK-dependent inhibition of NKCC1 activity. PMID: 27501334
    2. CB1 functionality increased with development at both central and peripheral level. PMID: 16519888
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane. Cell projection, axon. Cell junction, synapse, presynapse.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in neurons, especially in the olfactory bulbs, telencephalic pallium, and hypothalamus and also in the midbrain and hindbrain (in the mesencephalic tegmentum and dorsolateral rhombencephalon). Expressed also in the spinal cord.
  • 数据库链接：

    KEGG: xla:373759

    UniGene: Xl.21608