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  4. Recombinant Sheep Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1)

Recombinant Sheep Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1)

  • 中文名称：
    绵羊HSD11B1重组蛋白
  • 货号：
    CSB-CF010763SH
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    HSD11B1
  • Uniprot No.：
  • 别名：
    HSD11B1; Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1
  • 种属：
    Ovis aries (Sheep)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-292
  • 氨基酸序列
    AFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHINYTPLRVFSNDIHLLRRSLEVNLLSYVVLSTAALPMLKQTSGSIVVVSSVAGKIACPLAAAYSASKFALDGFFSSLRTEYEATKVNVSITLCILGLIDTDTAMKAVAGIYNAEASPKEECALEIIKGGALRQDEVYYDNSILTSLLLKNPGRKIMEFLSLKKYNMERFINN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
  • 基因功能参考文献：
    1. These results support the idea that the effects of HSD11B1-derived cortisol on conceptus elongation are indirectly mediated by the endometrium and are not directly mediated through GR in the trophectoderm PMID: 26085523
    2. Studies support the idea that IFNT and PGs from the conceptus regulate endometrial HSD11B1 expression and activity that regenerates bioactive cortisol in the ovine uterus during early pregnancy to influence endometrial functions and conceptus elongation. PMID: 22205698
    3. Endometrial epithelial HSD11B1 expression is induced by progesterone as well as stimulated by interferon tau and PTGS2-derived prostaglandins. PMID: 19696010
    4. hepatic expression of 11beta-hydroxysteroid dehydrogenase type 1 increased in placental restriction-hypoxic reduced liver growth PMID: 19208549
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 组织特异性：
    Liver, kidney, lung, hypothalamus, anterior pituitary and placenta.
  • 数据库链接：

    KEGG: oas:443409

    UniGene: Oar.418