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  4. Recombinant Saccharomyces cerevisiae Mitochondrial import receptor subunit TOM70 (TOM70)

Recombinant Saccharomyces cerevisiae Mitochondrial import receptor subunit TOM70 (TOM70)

  • 中文名称：
    酿酒酵母TOM70重组蛋白
  • 货号：
    CSB-CF024055SVG
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    TOM70
  • Uniprot No.：
  • 别名：
    TOM70; MAS70; OMP1; YNL121C; N1905; Mitochondrial import receptor subunit TOM70; 70 kDa mitochondrial outer membrane protein; Translocase of outer membrane 70 kDa subunit
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-617
  • 氨基酸序列
    MKSFITRNKTAILATVAATGTAIGAYYYYNQLQQQQQRGKKNTINKDEKKDTKDSQKETEGAKKSTAPSNPPIYPVSSNGEPDFSNKANFTAEEKDKYALALKDKGNQFFRNKKYDDAIKYYNWALELKEDPVFYSNLSACYVSVGDLKKVVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLERNLNKQAMSKLKEKFGDIDTATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFANYDESNEADKELMNGLSNLYKRSPESYDKADESFTKAARLFEEQLDKNNEDEKLKEKLAISLEHTGIFKFLKNDPLGAHEDIKKAIELFPRVNSYIYMALIMADRNDSTEYYNYFDKALKLDSNNSSVYYHRGQMNFILQNYDQAGKDFDKAKELDPENIFPYIQLACLAYRENKFDDCETLFSEAKRKFPEAPEVPNFFAEILTDKNDFDKALKQYDLAIELENKLDGIYVGIAPLVGKATLLTRNPTVENFIEATNLLEKASKLDPRSEQAKIGLAQMKLQQEDIDEAITLFEESADLARTMEEKLQAITFAEAAKVQQRIRSDPVLAKKIQETLAKLREQGLM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.
  • 基因功能参考文献：
    1. The Mim1 complex cooperates with the receptor Tom70 in binding of precursor proteins and promotes their insertion and assembly into the outer membrane. PMID: 21825073
    2. The import receptor Tom70, but not its partner Tom20, is in-volved in the initial recognition of the Ugo1 precursor. PMID: 21825074
    3. the malleability of the monomeric Tom70 receptor is an important factor in mitochondrial import PMID: 15316022
    4. The cytosolic fragment of yeast Tom70p (cTom70p) was crystallized. There are two Tom70p molecules in one asymmetric unit, which corresponds to a solvent content of approximately 51%. PMID: 16511318
    5. The crystal structure of Tom70p provides insights into the mechanisms of precursor transport across the mitochondrion's outer membrane. PMID: 16767096
    6. Data Show that Tom70 are anchored in the outer membrane by a single transmembrane alpha-helix, located at the N terminus of Tom70 (signal-anchored) and that Mim1 is required for efficient membrane insertion and assembly of Tom70. PMID: 17974559
    7. These data indicate an unexpected role for Tom70 in recruitment of soluble proteins to the mitochondrial surface, and indicate that Tom71 has a specialized role in Mfb1-mediated mitochondrial morphogenesis. PMID: 18007655
    8. Results suggest that the Tom70 monomer is the functional unit mediating initial chaperone docking and precursor recognition. PMID: 19358854

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  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass membrane protein.
  • 蛋白家族：
    Tom70 family
  • 数据库链接：

    KEGG: sce:YNL121C

    STRING: 4932.YNL121C