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  4. Recombinant Rat Vitamin K epoxide reductase complex subunit 1 (Vkorc1)

Recombinant Rat Vitamin K epoxide reductase complex subunit 1 (Vkorc1)

  • 中文名称：
    大鼠Vkorc1重组蛋白
  • 货号：
    CSB-CF740882RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Vkorc1
  • Uniprot No.：
  • 别名：
    Vkorc1; Vitamin K epoxide reductase complex subunit 1; Vitamin K1 2,3-epoxide reductase subunit 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-161
  • 氨基酸序列
    MGTTWRSPGRLRLALCLAGLALSLYALHVKAARARNEDYRALCDVGTAISCSRVFSSRWG RGFGLVEHVLGADSILNQSNSIFGCMFYTIQLLLGCLRGRWASILLILSSLVSVAGSLYL AWILFFVLYDFCIVCITTYAINAGLMLLSFQKVPEHKVKKP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
  • 基因功能参考文献：
    1. This study demonstrated that elevated CYP450 oxidative metabolism leading to accelerated difenacoum detoxification is involved in the Berkshire phenotype of L120Q mutation in Vkorc1. PMID: 29155484
    2. The aim of this study was to determine the distribution of VKORC1 1173C > T and VKORC1 -1639G > A polymorphisms, which are most important for warfarin therapy PMID: 24611351
    3. The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists. PMID: 23928358
    4. The differences in kinetics of VKOR activity between warfarin-resistant and sensitive rats were studied. PMID: 23018795
    5. identified, by using linkage information from three species the gene VKORC1 which encodes a small transmembrane protein of the endoplasmic reticulum; VKORC1 contains missense mutations in both human disorders and in a warfarin-resistant rat strain PMID: 14765194
    6. The genetic basis for resistance to anticoagulants lies in mutations in Vkorc1. PMID: 15879509
    7. An analysis of novel mutations show that the VKORC1 gene is the main target for spontaneous mutations conferring warfarin resistance. PMID: 19200363

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    VKOR family
  • 组织特异性：
    Highly expressed in liver. Detected at lower levels in lung, kidney and testis.
  • 数据库链接：

    KEGG: rno:309004

    STRING: 10116.ENSRNOP00000063977

    UniGene: Rn.97942