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  4. Recombinant Rat UDP-glucuronosyltransferase 2B7 (Ugt2b7)

Recombinant Rat UDP-glucuronosyltransferase 2B7 (Ugt2b7)

  • 中文名称：
    大鼠Ugt2b7重组蛋白
  • 货号：
    CSB-CF723476RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Ugt2b7
  • Uniprot No.：
  • 别名：
    Ugt2b7; Ugt2b8; UDP-glucuronosyltransferase 2B7; UDPGT 2B7; UGT2B7; UGT2B-RH4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-530
  • 氨基酸序列
    FRSGNCGKVLVWPLEYSHWMNLKIILDELVQRGHEVTVLRPSSSVSLDPKKASGLVYETS PTTSNNDEVEKSFYPVGDMWTYDVPKYTCLRYYPSLNKMFGQFSDLWLQLCREVVSNKEL IAKLKESQFDVVLSDAVGPCGELIAEILQLPFVYSLRFATAPGIEKYSAGQPFPPSYVPI ILSGFSGQMTFMERVENMLCLLYFDSWFESFPAKDWDPFFSEILGRPTTMVDTMKKAEIW LIRSYWDLEFPRPSLPNIEFVGGLHCQPAKPLPKEMEDFAQSSGEHGVWVFSLGSMIRNI TQERANTIASALAQIPQKVFWRFEGKKPDTLGPNTRVFKWIPQNDLLGHPKTKAFVTHGG ANGIYESIHYGIPPMVGIPLFAEQRDNVAHMVAKGAAVSIDFHTMSSSDLLNALKAVINN PSYKKKVMWLSAIHHDQPLKPLDRAVFWIEFVMRHKGAKHLRPLAHNLALVSVHSLDVIG FLLACVLAIVLLAVKCCLFLYRFFVKVAKNKRD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol,catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent.
  • 基因功能参考文献：
    1. Acute liver failure significantly increases the oral plasma exposure of zidovudine in rats, a result partly attributed to the impaired function and expression of hepatic UGT2B7 and intestinal P-gp. PMID: 28770824
    2. Data suggest that UGT2B7 is the predominant activity in liver microsomes for haloperidol O-glucuronidation (in both rat and human). PMID: 22028316
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    UDP-glycosyltransferase family
  • 数据库链接：

    KEGG: rno:286989

    UniGene: Rn.11131