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  4. Recombinant Rat Small conductance calcium-activated potassium channel protein 3 (Kcnn3)

Recombinant Rat Small conductance calcium-activated potassium channel protein 3 (Kcnn3)

  • 中文名称：
    大鼠Kcnn3重组蛋白
  • 货号：
    CSB-CF012085RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Kcnn3
  • Uniprot No.：
  • 别名：
    Kcnn3; Small conductance calcium-activated potassium channel protein 3; SK3; SKCa 3; SKCa3; KCa2.3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-732
  • 氨基酸序列
    MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQ LQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAI LHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCK YSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNA THNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV IETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMT YERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIA RVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVR VCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVV AVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRK HQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSL ESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISST SFPTPYTSSSSC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
  • 基因功能参考文献：
    1. SK3 was found in ventricular myocyte mitochondria. Agonists protected against ischemia-reperfusion injury in vivo. PMID: 28342809
    2. SK3 doesn't contribute to the enhanced ability of microglia to migrate and invade when in anti-inflammatory states. PMID: 25148577
    3. Whole-cell measurements of PC12 cells transfected with Endophilin A3 showed a reduction of KCa2.3 specific Cs(+) currents indicating that the interaction of Endophilin A3 with K(Ca)2.3 channels also occurs in mammalian cells PMID: 25096234
    4. the hormonal effect on SK3 caused by 17beta-estradiol includes divergent regulation at mRNA and protein levels. PMID: 24505302
    5. SK3 strongly increased during postnatal development and maintained throughout postnatal development and in the adult brain PMID: 24096910
    6. Data suggest that down-regulation of Kcnn3 in vascular endothelium in both male and female offspring of pregnant rats with elevated blood levels of testosterone/androgen (as in pre-eclampsia) may be involved in development of hypertension. PMID: 23966325
    7. A functional interplay of a trimeric complex that transforms incoming signals via SK3-channel activation into the local rearrangement of the cytoskeleton in early steps of neuronal differentiation involving nWASP and Abi-1 actin binding proteins. PMID: 21464958
    8. There was a statistically significant difference in Kcnn3 expression in studied brain regions after isolation rearing. PMID: 20662937
    9. Diabetes inhibits mRNA and protein expression of both SK3 and IK1 in the cavernous tissue of diabetic rats. This could play a key role in the development of erectile dysfunction in diabetic rats. PMID: 20364152
    10. Diabetes mellitus can significantly reduce erectile function in rats, which may be related to the decreased expression of SK3 in the corpus cavernosum. PMID: 20369552
    11. the SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits PMID: 14559917
    12. SK3-1C is a dominant-negative suppressor of SKCa and IKCa channels PMID: 14638680
    13. Variations in SK3 channel distribution and expression could contribute to differences in dopamine-related functions in the rat. PMID: 15170822
    14. Immunocytochemical localization of small-conductance, calcium-dependent potassium channels in astrocytes of the rat supraoptic nucleus. PMID: 16134141
    15. The GnRH neurones expressed transcripts for SK1-3 channels. PMID: 16627563
    16. N-C interactions influence SK3 channel function. PMID: 17167222
    17. Action potential activity evoked by motor neurons in muscle fibers is both necessary and sufficient to account for the physiological down-regulation of SK3 channels in the non-junctional membrane of skeletal muscle. PMID: 18703580
    18. Formation of cellular projections in neural progenitor cells depends on SK3 channel activity. PMID: 17459146

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel KCNN family, KCa2.3/KCNN3 subfamily
  • 数据库链接：

    KEGG: rno:54263

    STRING: 10116.ENSRNOP00000028117

    UniGene: Rn.10840