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  4. Recombinant Rat Reticulon-1 (Rtn1)

Recombinant Rat Reticulon-1 (Rtn1)

  • 中文名称：
    大鼠Rtn1重组蛋白
  • 货号：
    CSB-CF720677RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Rtn1; Nsp; Reticulon-1; Neuroendocrine-specific protein; S-rex
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-777
  • 氨基酸序列
    MAAPPDLQDEPLSPANPGSQLFGGRGEGEEATPKGARPAQQDGEPAWGSGAGAGVVSSRG LCSGPARSPPVAMETASTGVAAVPDALDHSSSPTLKDGEGACYTSLISDICYPPREDSAY FTGILQKENGHITTSESPEELGTPGPSLPEVPGTEPHGLLSSDSGIEMTPAESTEVNKIL ADPLDQMKAEACKYIDITRPQEAKGQEEQSPGLEDKDLDFKDKDSEVSTKPEGVHAPNQP SPVEGKLIKDNLFEESTFAPYIDELSDEQHRMSLVTAPVKITLTEIGPPVMTATHETIPE KQDLCLKPSPDTVPTVTVSEPEDDSPGSVTPPSSGTEPSAAESQGKGSVSEDELIAAIKE AKGLSYETTESPRPVGQAADRPKVKARSGLPTIPSSLDQEASSAESGDSEIELVSEDPMA SEDALPSGYVSFGHVSGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPK REQDSPPMKPGVLDAIREETSSRATEERAPSHQGPVEPDPILSFTPVTLQSRPEPSSGDG APVPEPPKSQQQKPEEEAVSSSQSPAATEIPGPLGSDLVPPLPFFNKQKAIDLLYWRDIK QTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKA YLELEITLSQEQIQKYTDCLQLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALF NGLTLLLMAVVSMFTLPVVYVKHQAQVDQYLGLVRTHINTVVAKIQAKIPGAKRHAE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
  • 基因功能参考文献：
    1. Collectively, these data support for the first time that RTN1-C may represent a novel candidate for therapies against cerebral ischemia/reperfusion injury. PMID: 28981095
    2. This study identified the intracellular calcium release channel ryanodine receptor 2 as a direct binding partner of RTN1A. PMID: 23454728
    3. neuroendocrine-specific protein-A (NSP-A) as ethanol-responsive gene in the fetal rat brain PMID: 12354640
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
  • 组织特异性：
    Expressed predominantly in central and peripheral nervous system of newborn and adult rats. Low levels have been also detected in heart, adrenal gland and spleen. Expression of isoform RTN1-B is restricted to particular neuronal types.
  • 数据库链接：

    KEGG: rno:116644

    UniGene: Rn.55126