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  4. Recombinant Rat Potassium voltage-gated channel subfamily A member 3 (Kcna3)

Recombinant Rat Potassium voltage-gated channel subfamily A member 3 (Kcna3)

  • 中文名称：
    大鼠Kcna3重组蛋白
  • 货号：
    CSB-CF012008RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Kcna3; Potassium voltage-gated channel subfamily A member 3; RCK3; RGK5; Voltage-gated potassium channel subunit Kv1.3; Voltage-gated potassium channel subunit Kv3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-525
  • 氨基酸序列
    MTVVPGDHLLEPEAAGGGGGDPPQGGCVSGGGCDRYEPLPPALPAAGEQDCCGERVVINI SGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIR RPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESS GPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGASSGASS FSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAER QGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVI LFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVL TIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYM VIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
  • 基因功能参考文献：
    1. The high stability and bioavailability, low normal-tissue uptake of [(64)Cu]Cu-NOTA-HsTX1[R14A], and accumulation in regions of up-regulated Kv channels both in vitro and in vivo demonstrate that HsTX1[R14A] represents a valuable lead for conditions treatable by blockade of the voltage-gated potassium channel Kv1.3. PMID: 28623364
    2. T-cell dependency on Kv1.3 or KCa3.1 might be irreversibly modulated by antigen exposure. PMID: 28248292
    3. PKC activation triggers down-regulation of Kv1.3 by inducing a clathrin-mediated endocytic event that targets the channel to lysosomal-degradative compartments. PMID: 28186199
    4. Kv1.3 may be a therapeutic target of interest for multiple sclerosis and add astrocytes to the list of cells whose activation would be suppressed by inhibiting Kv1.3 in inflammatory conditions PMID: 29574670
    5. Kv1.3 is involved in methamphetamine-mediated microglial damage PMID: 24533129
    6. Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life PMID: 24939846
    7. Kv1.3 appears to be distributed to the cis-Golgi membrane of rat astrocytes in a similar way as a Golgi resident protein. PMID: 24924920
    8. Results suggest that voltage-gated KV1.3 potassium channe represent effective targets for the treatment of allergic asthma. PMID: 24644290
    9. Identification of the Kv1.3 C-terminal signal sequence required for anterograde trafficking and surface expression. PMID: 24144698
    10. A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation PMID: 24244345
    11. The expression of Kv1.3 protein was significantly elevated in lymphocytes from SHR rats compared with that of the normotensive Wistar rats. PMID: 20717640
    12. Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model.( PMID: 22761436
    13. Two successive N-glycosylation consensus sites, N228NS and N229ST, are present on the S1-S2 linker of Kv1.3. Data suggest that Kv1.3 contains only one N-glycan and it is predominantly attached to N229 in the S1-S2 extracellular linker. PMID: 22613618
    14. Rat brain endothelial cells express Kv1.3, Kir2.1 and Kir2.2 K+ channels, all of which participate in setting membrane potential and could mediate K+ secretion into the brain interstitial fluid. PMID: 18026984
    15. This study supportes that Kv1.3 regulates the duration of the action potential in the presynaptic terminal of C fibers, limiting transmitter release to the postsynaptic cell. PMID: 21430270
    16. These findings underline the regulatory role of K(+) channels on the cell cycle and imply that K(+) channel modulators might be used therapeutically to activate endogenous NPCs.(Kv1.3 channel) PMID: 17029597
    17. Renal Kv1.3 channels participate in K(+) secretion and that apical membrane localization of Kv1.3 is enhanced in the intercalated cells by dietary K(+) loading. PMID: 20427469
    18. Kv1.3 potassium channels apparently contribute to cell-autonomous death of retinal ganglion cells through different components of the apoptotic machinery. PMID: 19696788
    19. KCNE4 (potassium voltage-gated channel subfamily E member 4), but not KCNE2, functions as an inhibitory Kv1.3 partner in leukocytes. PMID: 19773357
    20. Neurotrophin modulation of Kv1.3 channels through TrkB receptors is time and sensory experience dependent PMID: 12122142
    21. expression of the Kv1.3 subunit of the Kv1 family of voltage-gated potassium channels is predominant in rat prostate cancer cell lines PMID: 12838421
    22. KCNE4 beta-subunit has a drastic inhibitory effect on currents generated by Kv1.1 and Kv1.3 potassium channels PMID: 12944270
    23. Activated microglia killed postnatal hippocampal neurons through a process that requires Kv1.3 channel activity in microglia but not in neurons. PMID: 16079396
    24. T cells with other antigen specificities from these patients, or autoreactive T cells from healthy individuals and disease controls, express low levels of Kv1.3 and are predominantly naive or central-memory (T(CM)) cells PMID: 17088564
    25. implicate the traffic and localization of Kv1.3/Kv1.5 heteromers in the complex regulation of immune system cells PMID: 18218624
    26. Kv1.3 affects the function of postganglionic sympathetic neurons, which suggests that Kv1.3 influences sympathetic control of cardiovascular function PMID: 18614767

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.3/KCNA3 sub-subfamily
  • 数据库链接：

    KEGG: rno:29731

    STRING: 10116.ENSRNOP00000024372

    UniGene: Rn.44292