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  4. Recombinant Rat Potassium channel subfamily K member 9 (Kcnk9)

Recombinant Rat Potassium channel subfamily K member 9 (Kcnk9)

  • 中文名称：
    大鼠Kcnk9重组蛋白
  • 货号：
    CSB-CF861699RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Kcnk9
  • Uniprot No.：
  • 别名：
    Kcnk9; Task3; Potassium channel subfamily K member 9; Acid-sensitive potassium channel protein TASK-3; TWIK-related acid-sensitive K(+ channel 3; Two pore potassium channel KT3.2; Two pore K(+ channel KT3.2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-396
  • 氨基酸序列
    MKRQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAEEVRLRGKYNISSDDYQ QLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPL TLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTEVSMENMVTVGFFSCMGTLCLGAAAFSQ CEDWSFFHAYYYCFITLTTIGFGDFVALQSKGALQRKPFYVAFSFMYILVGLTVIGAFLN LVVLRFLTMNTDEDLLEGEVAQILAGNPRRVVVRVPQSRKRHHPMYFLRKYGRTLCYLCF PGANWGDDDDDDDDAVENVVVTTPVPPAVAAAAAAATPGPSTRNVRATVHSVSCRVEEIP PDVLRNTYFRSPFGAIPPGMHTCGENHRLHIRRKSI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    pH-dependent, voltage-insensitive, background potassium channel protein.
  • 基因功能参考文献：
    1. results demonstrate that neurotensin (NT) transiently increased the neuronal excitability of dentate gyrus granule cells (GCs) by inhibiting TASK-3 channels; NT-mediated increases in neuronal excitability facilitate long-term potentiation at the perforant path-GC synapses PMID: 25405940
    2. Hydroxy-alpha sanshool evokes colonic motility via blockage of the neural KCNK9 channel in the colonic myenteric plexus. PMID: 25634809
    3. the entire rat brain was immunocytochemically analyzed for expression of TASK-3 protein. PMID: 24077856
    4. Expression of the TASK-3 protein in motor systems of the rat central nervous system was examined. PMID: 22011781
    5. Results suggest that expression of TASK-2 and TASK-3 (but not TASK-1) undergoes age-related changes in dorsal root ganglion (DRG) neurons; TASK-2 and TASK-3 are likely to contribute to resting membrane potential in DRG neurons in neonates and adults. PMID: 22017174
    6. TASK-3 immunoreactivity was observed in neurons of the rat hippocampus PMID: 21710317
    7. Immunofluorescence double-labeling experiments with appropriate marker enzymes confirmed the expression of TASK-3 in cholinergic, serotoninergic, and noradrenergic neurons. PMID: 21082237
    8. mRNA expression of TASK3 was significantly higher in SHR than in WKY carotid bodies before hypertension developed. PMID: 20019330
    9. TASK-3 dominates the resting potassium conductance of zona glomerulosa cells PMID: 11875121
    10. Task3 distribution in the carotid body is limited to type I cells and vascular smooth muscle cells. PMID: 12231257
    11. TASK-3 mRNA is present in ventrolateral medulla neurons that regulate respiration or circulation (C1 adrenergic neurons). TASK channels are expressed by respiratory cells with putative rhythmogenic function and by premotor and motor neurons. PMID: 14519375
    12. Localization of the Task-3 protein was studied. PMID: 14574589
    13. role for TASK-3 in modulating cerebral synaptic transmission and responses to central nervous system active drugs PMID: 15178438
    14. first mutation found in a genetic model of absence epilepsy (GAERS), identified at the genomic level in the KCNK9 gene; a trinucleotide insertion, which expands a polyalanine region in the intracellular C-terminal tail of the TASK3 channel PMID: 15781965
    15. TASK3 and HCN2 channels stabilize the membrane potential by a mutual functional interactions. PMID: 16760342
    16. TASK-3 transcription is regulated by membrane potential via the calcineurin pathway PMID: 16864570
    17. Characterization of the 5' and 3' untranslated regions of TASK-3 gene involved in gene regulation. PMID: 16925981
    18. TASK-3-like background K(+) currents contribute to establishing membrane potential in striatal cholinergic interneurons PMID: 17167057
    19. Thus, neuronal excitability of PnC giant neurones in vivo is most likely increased by serotonergic projections via the K(2)P channel TASK-3. PMID: 18691333

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Two pore domain potassium channel (TC 1.A.1.8) family
  • 组织特异性：
    Highly expressed in the CNS and at lower levels in the colon, kidney, liver, lung, spleen, stomach and skeletal muscle. The highest expression was found in the olfactory nuclei, piriform cortex, cerebellum, antedorsal thalmic nucleus, pontine nucleus, dor
  • 数据库链接：

    KEGG: rno:84429

    STRING: 10116.ENSRNOP00000012408

    UniGene: Rn.48796