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  4. Recombinant Rat Parathyroid hormone/parathyroid hormone-related peptide receptor (Pth1r)

Recombinant Rat Parathyroid hormone/parathyroid hormone-related peptide receptor (Pth1r)

  • 中文名称：
    大鼠Pth1r重组蛋白
  • 货号：
    CSB-CF018988RA
  • 规格：
    ￥9720
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 别名：
    PTH/PTHrP type I receptor;PTH/PTHr receptor;Parathyroid hormone 1 receptor;PTH1 receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    65.2 kDa
  • 表达区域：
    27-591aa
  • 氨基酸序列
    DADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKASGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLPPATTNGHSQLPGHAKPGAPATETETLPVTMAVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
  • 基因功能参考文献：
    1. Results show the expression of PTHrP and its receptor, PTHR1, in the majority of neurons and glial cells in the SCG of rats. Expression of PTHrP, but not PTHR1 in the cytoplasm of SCG neurons is influenced by ovarian activity. PMID: 25278090
    2. Data indicate that PTH1R and PTHrP were more predominantly expressed in smooth muscle than in urothelium. PMID: 23546599
    3. Vav2 specifically interacted with activated Galpha(q) but not with Galpha(s) subunits, competing with PTHR for coupling to Galpha(q). PMID: 22554804
    4. Nicotine induces PTHrP expression in endothelial cells but excessive concentrations of nicotine reduce PTHrP receptor expression thereby attenuating any protective effects of PTHrP against apoptosis. PMID: 22508055
    5. Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains PMID: 21832055
    6. This study demonstrates the dynamic expression of EBP50 in vessels following injury and the effects of EBP50 on PTH1R function in vascular smooth muscle cells. PMID: 20843475
    7. These findings suggest that FGFR3 down-regulates PTH/PTHrP receptor gene expression via the JAK/STAT signaling in chondrocytic cells. PMID: 20356821
    8. Downregulation of PTHrP and PTHrP-R gene expression during late lung morphogenesis may cause pulmonary hypoplasia in the nitrofen CDH model, disrupting alveolar maturation and surfactant production by interfering with mesenchymal-epithelial interactions. PMID: 19855984
    9. The impaired secretory capacity of the parathyroid glands in uremic rats is significantly enhanced by PTHrP. An autocrine/paracrine role in the parathyroid glands of the PTH/PTHrP receptor targeting peptides, PTHrP and PTH, is suggested. PMID: 12787396
    10. a high P diet with subsequent decrease in serum Ca concentration suppressed the PTH action in the kidney due to PTH/PTHrP receptor mRNA down-regulation PMID: 15618618
    11. An examination of parathyroid hormone-related peptide (PTHrP) receptor mRNA expression in 6-week-old parathyroidectomized rats. PMID: 15630249
    12. findings show the calpain small subunit binds to the N-terminal portion of PTH1R's intracellular tail; calpain hydrolyzes the C-tail of PTH1R in a Ca2+- and ligand-dependent manner; the absence and reduction of calpain activity affect PTH1R signaling PMID: 15691895
    13. PTH1R forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta, and nuclear PTH1R is associated with the nucleoplasm PMID: 16574786
    14. parathyroid hormone-related peptide, by interaction with the PTH1 receptor, can increase tubulointerstitial cell survival and seems to act as a proinflammatory and profibrogenic factor in the FA-damaged kidney PMID: 16672315
    15. data demonstrate that angiotensin II acts via the angiotensin II type 1 receptor to destabilize parathyroid hormone receptor 1(PTH1R) mRNA in the renal vessel in the spontaneously hypertensive rats model of genetic hypertension PMID: 16728497
    16. osteoblast PTH1R expression down-regulated at both the protein and mRNA levels in the steady state of chronic renal failure PMID: 17384996
    17. Nuclear Localization Signal at residues 471-488 of the mature rat PTH1R is functional and plays a role in targeting the PTH1R the nucleus PMID: 17627912
    18. Results conclude that PTH and PTHrP bind similarly to the G protein-coupled PTHR conformation, PTH has a greater capacity to bind to the G protein-uncoupled conformation. PMID: 17872377
    19. Studies proposed that, in ROS cells, the presence of NHERF1 induces PTH-dependent calcium signaling by a cAMP-mediated mechanism that involves local protein kinase A-dependent activation of calcium channels. PMID: 18202147
    20. PTH signaling to PLC is negatively regulated by PTH/PTHrP receptor phosphorylation and PKA. PMID: 18450967
    21. Defective transport of mutant PTH receptor(Pro132Leu) to the experimental cell surface indicate a molecular basis for Blomstrand's chondrodysplasia. PMID: 18480546
    22. The regulation of PTH1R expression by endogenous PTHrP and the associated effects on vascular smooth muscle cell proliferation, was investigated. PMID: 19574446

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 数据库链接：

    KEGG: rno:56813

    STRING: 10116.ENSRNOP00000028435

    UniGene: Rn.48025