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  4. Recombinant Rat Leukotriene C4 synthase (Ltc4s)

Recombinant Rat Leukotriene C4 synthase (Ltc4s)

  • 中文名称：
    大鼠Ltc4s重组蛋白
  • 货号：
    CSB-CF013228RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Ltc4s
  • Uniprot No.：
  • 别名：
    Ltc4s; Leukotriene C4 synthase; LTC4 synthase; Glutathione S-transferase LTC4; Leukotriene-C(4 synthase
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-150
  • 氨基酸序列
    MKEETALLATVTLVGVLLQAYFSLQVISARRTFHVSPPLTSGPPEFERVFRAQVNCSEYF PLFLATLWVAGIFFHEGAAALCGLFYLFARLRYFQGYARSAQHRLDPLYASARALWLLVA MAALGLLVHFLPGTLRAALFRWLQVLLPMA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions.
  • 基因功能参考文献：
    1. LTC4S and Orai3 altered Akt signaling to promote VSMC migration and neointima formation. PMID: 25540197
    2. 5-LOX is involved in global cerebral ischemic damage in rats PMID: 23505109
    3. molecular cloning; elevated expression in rat basophilic leukemia-1 cells after treatment with retinoic acid PMID: 12445492
    4. Induction in basophilic leukemia cells with retinoice acid and actinomycin D; suppressed with methylprednisolone. PMID: 12767051
    5. LTC4S may be involved in acute systemic inflammatory responses such as fever and tachycardia. PMID: 15619010
    6. BRET data showed that hydrophobic regions 1 and 3 each allowed oligomerization to occur. These regions most likely form transmembrane helices, suggesting that homo-oligomerization of LTC4S is due to helix-helix interactions in the membrane. PMID: 16552728
    7. hepatic ischemia reperfusion injury up-regulated the mRNA and protein expressions of LTC4S in hepatocytes and sinusoidal endothelial cells and enhanced the activities of the LTC4 synthesis enzymes PMID: 17397868
    8. In the myeloid cells, but not in the epithelial cells, we observed that the leukotriene C(4) synthase promoter activity was stimulated by 12-O-tetradecanoylphorbol-13-acetate and all-trans-retinoic acid. PMID: 18053799
    9. Liver LTC4S was up-regulated in rat model of fulminant hepatic failure. PMID: 18461660

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  • 亚细胞定位：
    Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MAPEG family
  • 数据库链接：

    KEGG: rno:114097

    STRING: 10116.ENSRNOP00000004359

    UniGene: Rn.38594