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  4. Recombinant Rat Interferon-induced transmembrane protein 3 (ifitm3)

Recombinant Rat Interferon-induced transmembrane protein 3 (ifitm3)

  • 中文名称：
    大鼠ifitm3重组蛋白
  • 货号：
    CSB-CF011026RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    ifitm3
  • Uniprot No.：
  • 别名：
    ifitm3; Interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-137
  • 氨基酸序列
    MNHTSQAFVNAATGGQPPNYERIKEEYEVSELGAPHGSASVRTTVINMPREVSVPDHVVWSLFNTLFMNFCCLGFIAYAYSVKSRDRKMVGDMTGAQAYASTAKCLNISSLVLSILMVIITIVTVVIIALNAPRLQT
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
  • 基因功能参考文献：
    1. Ifitm3 is involved in the pathogenesis of glomerulonephritis via promoter hypermethylation that is associated with Ifitm3 repression in the rat strain susceptible to glomerulonephritis. PMID: 28213474
    2. Up-regulation of IFITM3 was observed during the heart development of Sprague-Dawley rats and the differentiation of H9C2 cells PMID: 22021094
    3. recruitment of rat8 to lipid membrane domains is a necessary step in mammary epithelial cell differentiation. PMID: 14766990
  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Early endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Cytoplasm, perinuclear region.
  • 蛋白家族：
    CD225/Dispanin family
  • 数据库链接：

    KEGG: rno:361673

    STRING: 10116.ENSRNOP00000020265

    UniGene: Rn.145191