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  4. Recombinant Rat High affinity copper uptake protein 1 (Slc31a1)

Recombinant Rat High affinity copper uptake protein 1 (Slc31a1)

  • 中文名称：
    大鼠Slc31a1重组蛋白
  • 货号：
    CSB-CF862390RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Slc31a1
  • Uniprot No.：
  • 别名：
    Slc31a1; Copt1; Ctr1; High affinity copper uptake protein 1; Copper transporter 1; rCTR1; Liver regeneration-related protein LRRGT00200; Solute carrier family 31 member 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-187
  • 氨基酸序列
    MRMNHMEMHHMGMNHTDDNITMPPHQHPTTSASHSHEMMMPMTFYFGFKNVDLLFSSLVI NTPGEMAGAFVAVFLLAMFYEGLKIAREGLLRKSQVSIRYNSMPVPGPNGTILMETHKTV GQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVV DITEHCH
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    High-affinity, saturable copper transporter involved in dietary copper uptake.
  • 基因功能参考文献：
    1. CTR1 and ATP7A play important roles in Cu transport in choroidal epithelial cells, and the Pb-induced intracellular Cu accumulation appears to be mediated, at least in part, via the alteration of CTR1 and ATP7A expression levels following Pb exposure. PMID: 24316150
    2. Data suggest that Ctr1 is responsible for transport (and accumulation) of copper salts (CuCl2; CuSO4) and organoplatinum compounds in dorsal root ganglion neurons; Ctr1 is thus involved in neurotoxicity of such antineoplastic drugs. PMID: 23123662
    3. Adult rat DRG tissue exhibits a specific pattern of expression of copper transporters with distinct subsets of peripheral sensory neurons intensely expressing either ATP7A or CTR1, but not both or ATP7B. PMID: 20836889
    4. Data show apical localization of Ctr1 in intestinal epithelia and suggest that increased Ctr1 apical localization in response to dietary copper limitation may represent an adaptive response to modulate Ctr1 availability at the site of copper absorption. PMID: 20699218
    5. The presence of mRNA and of immunoreactivity of the copper transport protein Ctr1 in astrocyte cultures suggests that Ctr1 contributes to the observed copper accumulation. PMID: 20004225
    6. It has been shown that SLC31A1 gene activity correlates with the rate of both intracellular and extracellular copper-containing enzymes formation. PMID: 16637264
    7. Prolactin stimulated Cu transport as a result of increased Ctr1 and Atp7A abundance at the plasma membrane in mammary gland PMID: 16741141

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in intestinal epithelial cells.
  • 蛋白家族：
    Copper transporter (Ctr) (TC 1.A.56) family, SLC31A subfamily
  • 数据库链接：

    KEGG: rno:171135

    STRING: 10116.ENSRNOP00000019544

    UniGene: Rn.2789