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  4. Recombinant Rat Beta-galactoside alpha-2,6-sialyltransferase 1 (St6gal1)

Recombinant Rat Beta-galactoside alpha-2,6-sialyltransferase 1 (St6gal1)

  • 中文名称：
    大鼠St6gal1重组蛋白
  • 货号：
    CSB-CF022759RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    St6gal1
  • Uniprot No.：
  • 别名：
    St6gal1; Siat1; Beta-galactoside alpha-2,6-sialyltransferase 1; Alpha 2,6-ST 1; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-403
  • 氨基酸序列
    MIHTNLKKKFSLFILVFLLFAVICVWKKGSDYEALTLQAKEFQMPKSQEKVAMGSASQVVFSNSKQDPKEDIPILSYHRVTAKVKPQPSFQVWDKDSTYSKLNPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLVTTEKRFLKDSLYTEGILIVWDPSVYHADIPKWYQKPDYNFFETYKSYRRLNPSQPFYILKPQMPWELWDIIQEISADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYDPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNIRC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.
  • 基因功能参考文献：
    1. Comparisons of the structure with pig ST3GAL1 and a bacterial sialyltransferase revealed a similar positioning of donor, acceptor, and catalytic residues that provide a common structural framework for catalysis PMID: 24155237
    2. ST6Gal-I regulates macrophage apoptosis via alpha2-6 sialylation of the TNFR1 death receptor. PMID: 21930713
    3. rat ST6GAL1 mRNA possess an L exon, suggesting conservation of this regulatory element in rodents PMID: 21098517
    4. Results suggest that ST6Gal I is cleaved initially between Leu(37) and Gln(38) by BACE1, and then the three-amino acid sequence at the NH(2) terminus is removed by exopeptidase(s) before secretion from the cells. PMID: 12473667
    5. BACE1 cleaves ST6Gal I in vivo and controls the secretion of the E41 form of the ST6Gal I protein PMID: 15364953
    6. soluble ST6Gal I produced by BACE1 plays, at least in part, a role in the sialylation of soluble glycoproteins PMID: 17897958
    7. There are two possible mechanisms for the upregulation of plasma ST6Gal I in hepatopathological situations: one accompanied by acute phase reactions to increase hepatic ST6Gal I expression and the other triggered by oxidative stress in the liver. PMID: 19150807
    8. The addition of rat alpha 2,6-sialyltransferase in a metabolically engineered baculovirus-infected insect cell system enables successful production of sialylated glycoprotein. PMID: 11437599

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  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 组织特异性：
    Expressed in hepatocytes (at protein level). Strongly expressed in liver, spleen, lung, kidney and submaxillary gland and weakly in heart and brain.; [Isoform RLA]: Expressed in liver.; [Isoform RKA]: Expressed in kidney, but not in liver.; [Isoform RKB]:
  • 数据库链接：

    KEGG: rno:25197

    STRING: 10116.ENSRNOP00000002499

    UniGene: Rn.54567