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Recombinant Rat Aquaporin-6 (Aqp6)

  • 中文名称：
    Recombinant Rat Aquaporin-6(Aqp6)
  • 货号：
    CSB-CF894353RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Aqp6
  • Uniprot No.：
  • 别名：
    Aqp6; Aquaporin-6; AQP-6
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-276
  • 氨基酸序列
    MEPGLCNRAYLLVGGLWTAISKALFAEFLATGLYVFFGVGSVLPWPVALPSVLQVAITFNLATATAVQISWKTSGAHANPAVTLAYLVGSHISLPRAVAYIAAQLAGATVGAALLYGVTPGGVRETLGVNVVHNSTSTGQAVAVELVLTLQLVLCVFASMDSRQTLGSPAAMIGTSVALGHLIGIYFTGCSMNPARSFGPAVIVGKFAVHWIFWVGPLTGAVLASLIYNFILFPDTKTVAQRLAILVGTTKVEKVVDLEPQKKESQTNSEDTEVSV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.
  • 基因功能参考文献：
    1. confirmed AQP6 expression in retinal ganglion cells and Muller cells in vitro PMID: 26526333
    2. AQP6 is involved in osmoregulation to maintain both the acid-base and osmotic balance of parotid secretory granules. PMID: 23183829
    3. AQP6 labeling of the outer plexiform layer was decreased in retinal slices from diabetic rats in comparison to slices from control rats. PMID: 21851171
    4. Aquaporin 6 is localized in glial membranes that surround the ribbon synapses in the outer plexiform layer of retina. PMID: 21185908
    5. the primary role of AQP6 may be in cellular regulation PMID: 12177001
    6. Data show that a single residue substitution totally eliminates the anion permeability of aquaporin 6 when expressed in Xenopus oocytes, but these oocytes exhibit significantly higher osmotic water permeability under basal conditions. PMID: 15671159
    7. The results suggest that AQP6 participates in water and anion transport in plasma membranes near tight junctions and in secretory granule membranes in rat parotid acinar cells. PMID: 18188600
    8. aquaporin-6 is distributed throughout the gastrointestinal tract. Its localization at the apical pole of superficial epithelial cells and its upregulation by feeding suggest it may be involved in movements of water and anions through villi epithelium. PMID: 19811639

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  • 亚细胞定位：
    Cytoplasmic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MIP/aquaporin (TC 1.A.8) family
  • 组织特异性：
    Kidney.
  • 数据库链接：

    KEGG: rno:29170

    STRING: 10116.ENSRNOP00000000323

    UniGene: Rn.48667