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  4. Recombinant Rat Acyl-CoA desaturase 1 (Scd1)

Recombinant Rat Acyl-CoA desaturase 1 (Scd1)

  • 货号：
    CSB-CF357086RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Scd1
  • Uniprot No.：
  • 别名：
    Scd1; Scd; Acyl-CoA desaturase 1; Delta(9-desaturase 1; Delta-9 desaturase 1; Fatty acid desaturase 1; Stearoyl-CoA desaturase 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-358
  • 氨基酸序列
    PAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDE EGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRL WSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHV GWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETF LHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHH AFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the Delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation. Plays an important role in body energy homeostasis. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides. Required for normal development of sebaceous glands. Required for the biosynthesis of normal levels of Delta-9 unsaturated fatty acids and 1-alkyl-2,3-diacylglycerol in the Harderian gland. Required for normal production of meibum, an oily material that prevents drying of the cornea.
  • 基因功能参考文献：
    1. Study in non-alcoholic fatty liver disease model in rats demonstrates that miR-192-5p has a negative regulatory role in lipid synthesis, which is mediated through its direct regulation of SCD-1. PMID: 29290651
    2. SCD1 overexpression in fatty liver disease is not affected by fasting after long-term fructose consumption in rats. Regulation of SCD1 plays an important role in fructose-induced hepatic steatosis. PMID: 27697525
    3. s investigated whether SCD1 activity is engaged in palmitate-induced pancreatic beta-cell autophagy PMID: 26293158
    4. SCD1 activity and SCD1 gene expression were considerably up-regulated in Goto-Kakizaki rats, and these levels were largely comparable to those in obese Zucker (fa/fa) rats. PMID: 23539346
    5. Adipose tissue stearoyl-CoA desaturase 1 index is increased in obesity-prone rats fed a high-fat diet. PMID: 23298201
    6. Data suggest that down-regulation of stearoyl-CoA desaturase Scd1 is a mechanism by which n-3 fatty acids repress constitutive triglyceride biosynthesis. PMID: 22047910
    7. SCD1 upregulation plays an important role in adaptation of oxidative muscle to endurance training. PMID: 20847127
    8. Describe a simple and robust method to quantitate Scd1 activity and its inhibition in primary rat hepatocytes. PMID: 20732836
    9. exercise training contributes to the proper regulation of fat metabolism by down-regulating hepatic SCD-1 gene expression and protein content. PMID: 19777326
    10. findings show show that stearoyl-CoA desaturase-SCD is involved in beta cell cytoprotective mechanism to fatty acid toxicity through its ability to transfer saturated FA into monounsaturated FA that are incorporated in lipids PMID: 19787047
    11. Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. The Scd1 gene represents a downstream target of hepatocellular tumor-modifier loci in two rodent species. PMID: 12419843
    12. SCD is degraded by a protease related to plasminogen PMID: 12928439
    13. role of leptin on stearoyl-CoA desaturase-1 mRNA expression in the liver and adipose tissue PMID: 14592417
    14. Insulin-resistant skeletal muscle of ZDF rats is characterised by a specific gene expression profile with increased levels of Scd1. Elevated SCD1 expression is a possible cause of insulin resistance and type 2 diabetes. PMID: 16284748
    15. SCD1 protein gene expression was elevated in the insulin-resistant "saturated fatty acid"-fed rats. PMID: 16357064
    16. Results suggest that stearoyl-CoA desaturase-1 is required for the onset of diet-induced hepatic insulin resistance. PMID: 16741579
    17. the gene expression of SCD1 is elevated in skeletal muscle after 2 wk of semistarvation and remains elevated in parallel to the phase of suppressed thermogenesis favoring catch-up fat during refeeding. PMID: 16809433
    18. Vitamin A decreases body weight gain in obese rat model independent of SCD1 gene regulation. PMID: 18364238
    19. stearoyl coenzyme A desaturase 1 transcript levels were 41% higher in ovariectomized rats compared with sham operation PMID: 18665039

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Fatty acid desaturase type 1 family
  • 组织特异性：
    Detected in liver (at protein level). Detected in adipose tissue. Detected in liver when rats are kept on a fat-free diet, but not when their food contains unsaturated fatty acids.
  • 数据库链接：

    KEGG: rno:246074

    STRING: 10116.ENSRNOP00000018447

    UniGene: Rn.1023