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Recombinant Rabies virus Glycoprotein (G)

  • 中文名称：
    Recombinant Rabies virus Glycoprotein (G)
  • 货号：
    CSB-CF357453RAG
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    G
  • Uniprot No.：
  • 别名：
    G; Glycoprotein
  • 种属：
    Rabies virus (strain Pasteur vaccins / PV) (RABV)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-524
  • 氨基酸序列
    KFPIYTIPDKLGPWSPIDIHHLSCPNNLVVEDEGCTNLSGFSYMELKVGYISAIKMNGFT CTGVVTEAETYTNFVGYVTTTFKRKHFRPTPDACRAAYNWKMAGDPRYEESLHNPYPDYH WLRTVKTTKESLVIISPSVADLDPYDRSLHSRVFPGGNCSGVAVSSTYCSTNHDYTIWMP ENPRLGMSCDIFTNSRGKRASKGSETCGFVDERGLYKSLKGACKLKLCGVLGLRLMDGTW VAMQTSNETKWCPPGQLVNLHDFRSDEIEHLVVEELVKKREECLDALESIMTTKSVSFRR LSHLRKLVPGFGKAYTIFNKTLMEADAHYKSVRTWNEIIPSKGCLRVGGRCHPHVNGVFF NGIILGPDGNVLIPEMQSSLLQQHMELLVSSVIPLMHPLADPSTVFKNGDEAEDFVEVHL PDVHERISGVDLGLPNWGKYVLLSAGALTALMLIIFLMTCWRRVNRSEPTQHNLRGTGRE VSVTPQSGKIISSWESYKSGGETGL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
  • 基因功能参考文献：
    1. results demonstrate that G-mediated dendritic cell activation is regulated by the ectodomain while the level of G expression by the cytoplasmic tail domain PMID: 28161580
    2. Characterization of epitopes on the rabies virus glycoprotein by selection and analysis of escape mutants has been described. PMID: 27132040
    3. Data suggest that two copies of the glycoprotein gene could be a potential candidate in the development of novel inactivated rabies vaccines. PMID: 24498294
    4. N-glycosylation at position 37, but not at position 146 of G protein reduces pathogenicity. PMID: 24177272
    5. G proteins lacking an N-glycan at Asn(319) failed to fold into their correct structure and lost their fusion activity, indicating that Asn(319) N-glycosylation is important for the functional expression of street virus G proteins. PMID: 23114627
    6. human PCBP2 specifically and selectively interacts with rabies virus glycoprotein mRNA and this interaction may contribute to the post-transcriptional regulation of glycoprotein expression PMID: 22438951
    7. N-glycosylation sites in the G protein is one of the determinants of the pathogenicity of rabies virus. PMID: 22248643
    8. The s conclude that the expression level of the glycoprotein gene does have an impact on pathogenicity but is not a dominant factor that determines pathogenicity. PMID: 21068252
    9. R333Q mutation in the G protein is crucial for the attenuation of Flury rabies virus in mice. PMID: 20538851
    10. attenuation of rabies virus requires expansion of the set of host PDZ proteins with which G interacts, which interferes with the finely tuned homeostasis required for survival of the infected neuron PMID: 20086240
    11. Amino acid substitutions of G protein affect efficiency of cell-to-cell spread but not apoptosis-inducing ability. PMID: 20377742
    12. concluded that functional maturation of G protein to acquire fusogenic activity is correlated with 1-30-44 epitope formation PMID: 15557743
    13. trimerization is required for efficient interaction with p75NTR PMID: 16099913
    14. results presented here show that at least three amino acids at positions 242, 255 and 268 of the G protein are essential for the pathogenicity of the Nishigahara strain PMID: 16188341
    15. We confirmed that an arginine at position 333 in G protein contributed to reversion of the pathogenicity in a highly attenuated HEP-Flury strain of rabies virus. PMID: 16473429

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  • 亚细胞定位：
    Virion membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Lyssavirus glycoprotein family
  • 数据库链接：

    KEGG: vg:1489856