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Recombinant Polycystin-2 (pkd-2)

  • 中文名称：
    秀丽隐杆线虫pkd-2重组蛋白
  • 货号：
    CSB-CF883324CXY
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    pkd-2
  • Uniprot No.：
  • 别名：
    pkd-2; pdk-2; Y73F8A.1; Polycystin-2; CePc2; Polycystic kidney disease 2 protein homolog
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-716
  • 氨基酸序列
    MNYGAADERWANPPQPVAAAEHGPSFDHSMVSEEYEHDKKKNPAQKEGISFSQALLASGH EKSDGKIKLTARSFMEVGGYAVFLIVLVYVAFAQNSIQSYYYSKVMSDLFVASTGASGAP AFGSCTSMDNIWDWLSQVLIPGIYWTETSNSTDNENMIYYENRLLGEPRIRMLKVTNDSC TVMKSFQREIKECFANYEEKLEDKTMVGDGSVDAFIYATAKELENLKTVGTIASYGGGGF VQRLPVAGSTEAQSAIATLKANRWIDRGSRAIIVDFALYNANINLFCVVKLLFELPASGG VITTPKLMTYDLLTYQTSGGTRMMIFEGIFCGFILYFIFEELFAIGRHRLHYLTQFWNLV DVVLLGFSVATIILSVNRTKTGVNRVNSVIENGLTNAPFDDVTSSENSYLNIKACVVFVA WVKVFKFISVNKTMSQLSSTLTRSAKDIGGFAVMFAVFFFAFAQFGYLCFGTQIADYSNL YNSAFALLRLILGDFNFSALESCNRFFGPAFFIAYVFFVSFILLNMFLAIINDSYVEVKA ELARKKDGEGILDWFMNKVRGLTKRGKRPDAPGEDATYEDYKLMLYRAGYAEKDINEAFT RFNVTSMTEHVPEKVAEDIADEVARMTEQKRNYMENHRDYANLNRRVDQMQESVFSIVDR IEGVNATLQTIEKQRVQQQDGGNLMDLSALLTNQVRNRESAARRPTITSIADKKEE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a calcium permeable cation channel. Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as lov-1 and atp-2 in response behavior.
  • 基因功能参考文献：
    1. acts as a major calcium-release channel in the endoplasmic reticulum in cells where rapid calcium signaling is required, and is essential in those excitable cells for rapid responses to stimuli (polycystin-2) PMID: 15862350
    2. Both general and cell-type-specific factors govern TRPP2/PKD-2 subcellular distribution by forming at least two steps involving somatodendritic and ciliary sorting decisions. PMID: 16943275
    3. Results demonstrate that somatodendritic and ciliary targeting of PKD-2 requires the transmembrane region of PKD-2 and that the PKD-2 cytosolic termini regulate subcellular distribution and function. PMID: 18037411
    4. 11 mutants found with defects in the ciliary localization (cil) of C. elegans PKD-2, a transient receptor potential polycystin (TRPP) channel PMID: 18407554
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Cell projection, cilium. Cell projection, axon. Cell projection, dendrite. Perikaryon. Endoplasmic reticulum membrane.
  • 蛋白家族：
    Polycystin family
  • 组织特异性：
    Exclusively expressed in a subset of 3 categories of adult male sensory neurons: ray neurons, hook neurons and head cephalic (CEM) neurons. Expressed in the male tail.
  • 数据库链接：

    KEGG: cel:CELE_Y73F8A.1

    STRING: 6239.Y73F8A.1

    UniGene: Cel.12535