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  4. Recombinant Mouse Type-1A angiotensin II receptor (Agtr1a)

Recombinant Mouse Type-1A angiotensin II receptor (Agtr1a)

  • 中文名称：
    Recombinant Mouse Type-1A angiotensin II receptor(Agtr1a)
  • 货号：
    CSB-CF001465MO(A4)
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Agtr1a
  • Uniprot No.：
  • 别名：
    Agtr1a; Agtr1Type-1A angiotensin II receptor; Angiotensin II type-1A receptor; AT1A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-359AA
  • 氨基酸序列
    MALNSSTEDGIKRIQDDCPRAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKIADIVDTAMPITICIAYFNNCLNPL FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSAAKKPASCSEVE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    10xHis-SUMO-tag
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能参考文献：
    1. Results provide support of a direct role of BM-derived cells AT1R in Ang II-induced atherosclerosis burden and plaque vulnerability. AT1R activation promotes hepatic mRNA expression of cholesterol-metabolism-related genes and vascular mRNA expression of pro-inflammatory cytokines. PMID: 30181481
    2. High AT1 receptor expression is associated with myocardial infarction. PMID: 29269324
    3. GPCR-arrestin complex initiates non-desensitized signalling at the plasma membrane by coupling with ion channels. PMID: 28181498
    4. the expression of AT2 receptors was significantly increased compared to that of AT1 receptors upon ischemic induction. PMID: 29710550
    5. Transforming growth factor-beta1 induces cerebrovascular dysfunction and astrogliosis through angiotensin II type 1 receptor-mediated signaling pathways PMID: 29505736
    6. High AT1R expression is associated with acute lung injury. PMID: 29990483
    7. QLQX may improve diabetic cardiac function by regulating AGTR1/ TRPV1-mediated autophagy in STZ-induced diabetic mice. PMID: 29929188
    8. Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms. PMID: 28434702
    9. AT1R in antigen-specific CD8(+) T cells regulates expansion, differentiation, and function during effector and memory phases of the response against Plasmodium, which could apply to different infectious agents. PMID: 27782175
    10. Homocysteine displaces angiotensin II, exaggerating injury in abdominal aortic aneurysm. PMID: 29296021
    11. Nrf2-mediated stimulation of intrarenal Renin-angiotensin system gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes. PMID: 29211853
    12. This study aimed to define whether sex chromosome complement (SCC) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney. PMID: 28254489
    13. The formation of liver metastasis, in a mouse model of colorectal cancer, correlated with collagen deposition in the metastatic area, which was dependent on AT1a signaling. PMID: 28660748
    14. Perivascular Adipose Tissue Angiotensin II Type 1a Receptor Promotes Vascular Inflammation and Aneurysm formation in apolipoprotein E-deficient (ApoE(-/-)) mice. PMID: 28760942
    15. Mice lacking the AT1A receptor specifically in LEPR-expressing cells failed to show an increase in resting metabolic rate in response to a high-fat diet and deoxycorticosterone acetate-salt (DOCA-salt) treatments, but blood pressure control remained intact. PMID: 28263184
    16. In wild-type, total (tNCC) and phosphorylated (pNCC) NCC protein expressions were 1.8- and 4.6-fold higher in females compared with males, consistent with the larger response to HCTZ. In AT1a receptor knockout mice, tNCC and pNCC increased significantly in males to levels not different from those in females. PMID: 28566500
    17. This study showed that activation of the AT1a receptor may contribute to maintenance of the glomerular structure against hypertensive renal damage. PMID: 27663860
    18. Altered expression of AT1 and AT2 receptors with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneration. PMID: 27763643
    19. Results provide evidence that blockade of the AT1a receptor could have some effects on browning of WAT, with inhibitory effects on adipose tissue-derived stem cells differentiation into adipocytes. PMID: 27992452
    20. Results suggest the involvement of angiotensin II (Ang II), through its angiotensin type-1 receptor (AT1R) in the inflammation induced by Aah venom, in the heart and the aorta. PMID: 27955986
    21. highly and selectively expressed in colonic L cells PMID: 27447725
    22. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. PMID: 27330080
    23. hydronephrosis observed in ATr1A(-/-) mouse kidneys does not arise from a failure in the development of the essential pacemaker and contractile machinery driving pyeloureteric peristalsis PMID: 26876143
    24. Genetic inhibition of Gpx1 potentiates cocaine-induced renal damage via activation of AT1R by inhibition of PI3K-Akt signaling. PMID: 26930476
    25. AT1R up-regulation in the stomach may help compensate for interstitial cells of Cajal loss in diabetic mice. PMID: 26773730
    26. These results suggest that in the absence of AT2R, wound healing rate is accelerated, but yielded worse skin quality. PMID: 26727887
    27. Results indicate that Ang III produces nociceptive behavior similar to Ang II, and suggest that the phosphorylation of p38 MAPK mediated through AT1 receptors on spinal astrocytes and neurons contributes to Ang II- and III-induced nociceptive behavior PMID: 26209257
    28. Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors PMID: 26227882
    29. Angiotensin type 1a receptor deficiency decreases amyloid beta-protein generation and ameliorates brain amyloid pathology PMID: 26154270
    30. CRF-AT1a R((-/-)) mice exhibit less freezing than wild-type mice during tests of conditioned fear. PMID: 26257395
    31. Results support functional interactions between AT1 receptors and TLR4 in mediating ANG II-dependent microglial activation and oxidative stress within the hypothalamic paraventricular nucleus. PMID: 26637556
    32. These results indicate that Ang-II induces cardiac fibroblast proliferation and migration in part via Nox4/ROS-dependent IL-18 induction and MMP9 activation, and may involve AT1/Nox4 physical association. PMID: 26445208
    33. AT1 receptor contributes to plantaris muscle development and hypertrophy via atrogin-1 PMID: 26025227
    34. hGRK4gamma(142V) phosphorylates histone deacetylase type 1 and promotes its nuclear export to the cytoplasm, resulting in increased AT1R expression and greater pressor response to angiotensin II. PMID: 26667412
    35. these data demonstrate that a state of pre-hypertrophic compensated dysfunction can exist in affected individuals before common markers of heart disease are detectable. PMID: 26092119
    36. These findings suggest that direct actions of AT1A receptors in vascular smooth muscle cells are essential for regulation of renal blood flow by angiotensin II. PMID: 25855778
    37. endothelial ATR and cytoskeletal dysregulation have roles in vasculopathy-associated hyperangiotensinemia mobilization of hematopoietic stem cells/progenitors PMID: 25574809
    38. Findings suggest that angiotensin II type 1 receptor activation plays an important role in the development of heart failure and ventricular arrhythmia in Galphaq-TG mouse model of heart failure. PMID: 25171374
    39. AT1a receptor depletion in fibroblasts attenuates Ang II-induced medial hyperplasia in the ascending aorta. PMID: 26160957
    40. ACE2 deficiency worsened the influenza pathogenesis markedly, mainly by targeting the angiotensin II type 1 receptor (AT1). PMID: 25391767
    41. Female myocytes with elevated AngII appear more susceptible to an age-related contractile deficit, whereas male AngII-TG myocytes preserve contractile function with age PMID: 24566994
    42. These results suggest a novel mechanism of Ang II action in bone metabolism that is mediated by TGFbeta and targets proliferation of osteoblast progenitors. PMID: 25556973
    43. Testosterone prevents pancreatic beta-cell apoptosis due to glucotoxicity through reduction of the expression of ATGR1 and its signaling pathway. PMID: 25512346
    44. Suggest that myogenic tone is determined by AT1 and CysLT1 receptors acting together as mechanosensors via Gq/11-protein activation. PMID: 25395620
    45. ATR expression was upregulated in brain stem astrocytes in MI-induced heart failure, which worsened LV remodeling and prognosis via sympathoexcitation. PMID: 25217656
    46. irbesartan-induced beneficial suppressive effect on the leptin-IL-6 axis in the adipose tissue in KKAy mice is partly mediated by a trend of up-regulation of the adipose ATRAP/AT1R ratio as one of pleiotropic effects of irbesartan. PMID: 24834011
    47. AT1-independent MR activation in the LV might be responsible for the pathogenesis of diabetic cardiomyopathy. PMID: 24664319
    48. Mechanical stress triggers cardiomyocyte autophagy through AT1 receptor-mediated activation of p38MAP kinase independently of angiotensin II. PMID: 24586922
    49. Uptake of ANG II and downstream MAP kinases ERK1/2 and NHE3 signaling responses in proximal tubule cells are mediated primarily by AT1a receptors. PMID: 24740791
    50. The AT1a receptor is not required for the development of diabetic cardiomyopathy. PMID: 24215514

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:11607

    STRING: 10090.ENSMUSP00000070958

    UniGene: Mm.35062