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  4. Recombinant Mouse Trimeric intracellular cation channel type A (Tmem38a)

Recombinant Mouse Trimeric intracellular cation channel type A (Tmem38a)

  • 中文名称：
    小鼠Tmem38a重组蛋白
  • 货号：
    CSB-CF663629MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Tmem38a
  • Uniprot No.：
  • 别名：
    Tmem38a; Trimeric intracellular cation channel type A; TRIC-A; TRICA; 27 kDa sarcoplasmic reticulum protein; Mitsugumin-33A; SPR-27; Transmembrane protein 38A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-298
  • 氨基酸序列
    MDLMSALSLGELALSFSRVPLFPVFDLSYFIVSIIYLKYEPGAVELSRRHPVASWLCAML HCFGSYILADLLLGEPIIDYFSNSSSILLASGVWYLIFFCPLDLFYKCVCFLPVKLIFVA MKEVVRVRKIAVGIHHAHHHYHHGWFIMIATGWVKGSGVALLSNVEQLLRGVWKPETNEI LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFVFTMFMVSCKVFLTATHSHSSPFDIL EGYICPVLFGATWGGDHHHDNHGAPHGMGLGTQHSGLPAKAKEELGEGSRKKKTKKAD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
  • 基因功能参考文献：
    1. Three muscle-specific nuclear membrane proteins, NET39, Tmem38A, and WFS1, direct specific myogenic genes to the nuclear periphery to facilitate their repression during myogenesis. PMID: 27264872
    2. TRIC-A and TRIC-B seem to have differential functions in Ca(2+) signaling in excitable and nonexcitable cells. PMID: 24526676
    3. TRIC-A channel density in VSMCs is responsible for controlling basal blood pressure at the whole-animal level. PMID: 23592776
    4. TRIC-A channels contribute to maintaining blood pressure, while TRIC-A SNPs could provide biomarkers for constitutional diagnosis and personalized medical treatment of essential hypertension. PMID: 21803293
    5. Absence of TRIC-A leads to instability of Ca(2+) movement across the sarcoplasmic reticulum membrane. PMID: 20858894
    6. TRIC channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores PMID: 17611541

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  • 亚细胞定位：
    Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane.
  • 蛋白家族：
    TMEM38 family
  • 组织特异性：
    Expressed at high levels in heart and striated muscle. Also detected in brain, lung and kidney.
  • 数据库链接：

    KEGG: mmu:74166

    STRING: 10090.ENSMUSP00000034244

    UniGene: Mm.212927