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  4. Recombinant Mouse Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1)

Recombinant Mouse Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1)

  • 中文名称：
    小鼠Tmub1重组蛋白
  • 货号：
    CSB-CF884959MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Tmub1
  • Uniprot No.：
  • 别名：
    Tmub1; Hops; Transmembrane and ubiquitin-like domain-containing protein 1; Hepatocyte odd protein shuttling protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-245
  • 氨基酸序列
    MALIEGVGDEVTVLFAVLACLLVLALAWVSTHTTESTDPQPQPPGTTTPAQPSEAMSASD SIREEAPGAESPSLRHRGPSAQPEPDTGVTASTPPDSPQEPLLLRLKFLNDSEQVARAWP QDTIGSLKRTQFPGQEQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPHPP CPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAF AMYRP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface. Acts as negative regulator of hepatocyte growth during regeneration.; May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation. May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1.
  • 基因功能参考文献：
    1. HOPS has distinct, isoform-specific functions in the nucleolus, nucleus, and cytoplasm. PMID: 24240191
    2. HOPS acts as a functional bridge in the interaction between NPM and p19(Arf) PMID: 22890319
    3. results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG PMID: 20582322
    4. HOPS is involved in centrosome assembly and maintenance. PMID: 18418082
    5. transmission; it contributes to maintain the synaptic surface number of the GluR2-containing AMPARs by facilitating the recycling of GluR2 to the plasma membrane PMID: 18665261

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Recycling endosome. Cytoplasm. Nucleus. Nucleus, nucleolus.; [Isoform 1]: Membrane.; [Isoform 2]: Membrane.; [iHOPS]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, nucleolus. Nucleus.
  • 组织特异性：
    Expressed in adult brain; at protein level. Isoform 1 (lHOPS) is highly expressed in small intestine, stomach and epididymis. Isoform 2 (sHOPS) and iHOPS are abundantly expressed in brain, liver and adrenal gland.
  • 数据库链接：

    KEGG: mmu:64295

    STRING: 10090.ENSMUSP00000030799

    UniGene: Mm.150098