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Recombinant Mouse Syndecan-2 (Sdc2)

  • 中文名称：
    小鼠Sdc2重组蛋白
  • 货号：
    CSB-CF020889MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Sdc2
  • Uniprot No.：
  • 别名：
    Sdc2; Hspg1; Synd2; Syndecan-2; SYND2; Fibroglycan; Heparan sulfate proteoglycan core protein; HSPG; CD antigen CD362
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-202
  • 氨基酸序列
    ETRTELTSDKDMYLDNSSIEEASGVYPIDDDDYSSASGSGADEDIESPVLTTSQLIPRIPLTSAASPKVETMTLKTQSITPAQTESPEETDKEEVDISEAEEKLGPAIKSTDVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis.
  • 基因功能参考文献：
    1. We used a transgenic mouse model with high syndecan-2 expression in osteoblasts to enrich the bone surface with cellular glycosaminoglycans ..syndecan-2 overexpression increased apoptosis of mesenchymal precursors within the bone marrow PMID: 28661485
    2. Syndecan-2 expression is upregulated in colonic epithelia of mice with DSS-induced colitis via FOXO3 activation. PMID: 28031321
    3. In mouse melanoma cells, siRNA-mediated knockdown of syndecan-2 was associated with reduced melanin synthesis, whereas overexpression of syndecan-2 increased melanin synthesis. PMID: 24472179
    4. The repression of syndecan-2 by Wnt/beta-catenin/TCF signaling contributes to the resistance of osteosarcoma cells to doxorubicin. PMID: 22550000
    5. MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression. PMID: 22493442
    6. Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphogenesis. PMID: 21555464
    7. RGD-independent cell adhesion via a tissue transglutaminase 2-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and {alpha}5{beta}1 integrin co-signaling. PMID: 20929862
    8. The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones. PMID: 11931647
    9. role in dendritic spine morphogenesis PMID: 12073610
    10. Syndecan-2 mRNA transcripts are expressed by reactive astrocytes in the region surrounding the necrotic brain tissue, exhibiting peak levels at day 7 after cryo-injury. PMID: 12112370
    11. HSPG and LRP together participate in VLDL clearance by means of a synergistic relationship. PMID: 12598530
    12. syndecan-2 has a role in the integration of signals from soluble and insoluble factors PMID: 14642532
    13. In the present study, two Lewis lung carcinoma-derived clones express syndecan 2 and syndecan 4 cooperating in situ in actin cytoskeletal organization. PMID: 14999018
    14. Syndecan-2 is necessary for angiogenesis of microvascular endothelial cells, proangiogenic factors expressed during glioma progression regulate S2 shedding, and shed S2 ectodomain may increase endothelial cell angiogenic processes PMID: 16574663
    15. Study examined the effects of stable syndecan-2 overexpression on programmed cell death, finding that syndecan-2 transfected cells were more sensitive to apoptosis induced by serum-withdrawal than control cells. PMID: 17041758
    16. syndecan-2 acts as a suppressor for MMP-2 activation, causing suppression of metastasis PMID: 17623663
    17. Data show that unilateral nephrectomy leads to up-regulation of syndecan-2- and TGF-beta-mediated glomerulosclerosis in syndecan-4 deficient male mice. PMID: 17681770
    18. An alternate pathway mediated by the extracellular domains of syndecans-2 and -4 is characterized that is independent of both heparan sulphate and syndecan signaling. PMID: 17870067
    19. Syndecan-2 plays a crucial role in the migratory potential of melanoma cells. PMID: 19641225

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Syndecan proteoglycan family
  • 组织特异性：
    Preferential expression in cells of mesenchymal origin.
  • 数据库链接：

    KEGG: mmu:15529

    STRING: 10090.ENSMUSP00000022871

    UniGene: Mm.234266