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  4. Recombinant Mouse Sulfhydryl oxidase 1 (Qsox1)

Recombinant Mouse Sulfhydryl oxidase 1 (Qsox1)

  • 中文名称：
    小鼠Qsox1重组蛋白
  • 货号：
    CSB-CF806410MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Qsox1
  • Uniprot No.：
  • 别名：
    Qsox1; Qscn6; Sox; Sulfhydryl oxidase 1; mSOx; Quiescin Q6; Skin sulfhydryl oxidase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    33-748
  • 氨基酸序列
    ARLSVLYSSSDPLTLLDADSVRPTVLGSSSAWAVEFFASWCGHCIAFAPTWKELANDVKD WRPALNLAVLDCAEETNSAVCREFNIAGFPTVRFFQAFTKNGSGATLPGAGANVQTLRMR LIDALESHRDTWPPACPPLEPAKLNDIDGFFTRNKADYLALVFEREDSYLGREVTLDLSQ YHAVAVRRVLNTESDLVNKFGVTDFPSCYLLLRNGSVSRVPVLVESRSFYTSYLRGLPGL TRDAPPTTATPVTADKIAPTVWKFADRSKIYMADLESALHYILRVEVGKFSVLEGQRLVA LKKFVAVLAKYFPGQPLVQNFLHSINDWLQKQQKKRIPYSFFKAALDSRKEDAVLTEKVN WVGCQGSEPHFRGFPCSLWVLFHFLTVQANRYSEAHPQEPADGQEVLQAMRSYVQFFFGC RDCADHFEQMAAASMHQVRSPSNAILWLWTSHNRVNARLSGALSEDPHFPKVQWPPRELC SACHNELNGQVPLWDLGATLNFLKAHFSPANIVIDSSASRHTGRRGSPEATPELVMDTLK LESRNSVLGHEQAASAESPGATALDVPAEKPEASGPQELYTGLRMGGASPGQGPPERMED HQRDMQENAPGQQHLSKRDTEALFLPEVNHLQGPLELRRGGRSPKQLAPILEEEPEALAI QGQGQWLQVLGGGISHLDISLCVGLYSVSFMGLLAMYTYFRARLRTPKGHASYPTA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
  • 基因功能参考文献：
    1. Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms, in particular, by the serum QSOX1. PMID: 27581528
    2. QSOX1 inhibits autophagy in breast cancer cells. PMID: 24475161
    3. crystal structure PMID: 22801504
    4. cloned skin SOx cDNA and characterized it as one of the disulfide (S-S) cross-linking enzymes PMID: 12354420
    5. In seminiferous tubules, where a high level of expression was noticed, QSOX might play an important physiological role in sperm function and serve as a marker for the diagnosis of male infertility. PMID: 16160860

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  • 亚细胞定位：
    [Isoform 1]: Golgi apparatus membrane; Single-pass membrane protein. Secreted.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.
  • 蛋白家族：
    Quiescin-sulfhydryl oxidase (QSOX) family
  • 组织特异性：
    Detected in skin (at protein level). Expressed in the seminal vesicles and skin.
  • 数据库链接：

    KEGG: mmu:104009

    STRING: 10090.ENSMUSP00000035658

    UniGene: Mm.27035