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  4. Recombinant Mouse Sodium channel subunit beta-1 (Scn1b)

Recombinant Mouse Sodium channel subunit beta-1 (Scn1b)

  • 中文名称：
    小鼠Scn1b重组蛋白
  • 货号：
    CSB-CF020835MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Scn1b
  • Uniprot No.：
  • 别名：
    Scn1b; Sodium channel subunit beta-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-218
  • 氨基酸序列
    GGCVEVDSDTEAVYGMTFKILCISCKRRSETTAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
  • 基因功能参考文献：
    1. This study demonstrated that the sodium channel beta1 subunit proteins encoded by this mutant gene are expressed at the surface of neuronal cell bodies. PMID: 27277800
    2. Loss of Scn1b caused increased amplitude of tetrodotoxin-sensitive INa, delayed after-depolarizations, triggered beats, changed Ca2+ transients,and susceptibility ventricular arrhythmias. PMID: 25772295
    3. Study showed that Scn1b is widely expressed at axon initial segments across the mouse brain, there is considerable heterogeneity in the proportion of Scn1b-positive neurons and the amount of expression between and within brain regions PMID: 25421039
    4. beta1-beta3 is more likely to form a di-polymer than beta1-beta1 based on molecular interaction analysis, including potential energy analysis PMID: 24581800
    5. Scn1b mutant subicular and layer 2/3 pyramidal neurons had increased action potential firing rates, presumably as a consequence of their increased input resistance PMID: 24747835
    6. Scn1b is critical for neuronal proliferation, migration, and pathfinding during the critical postnatal period of brain development. PMID: 23277545
    7. Scn1b regulates the electrical excitability of nociceptive DRG neurons in vivo by modulating both I(Na) and I(K). PMID: 21555511
    8. propose reciprocity of function between Scn1b (beta1) and Na(v)1.6 such that beta1-mediated neurite outgrowth requires Na(v)1.6-mediated I(Na), and Na(v)1.6 localization and consequent high-frequency firing require beta1 PMID: 20133873
    9. Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons PMID: 15452131
    10. Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b. PMID: 17868089
    11. Electrocardiograms from Scn1b knockout mice displayed longer heart rate intervals and extended long QT syndromes. PMID: 17884088
    12. Voltage-gated Na(+) channel beta1 subunits signal via multiple pathways on multiple timescales and play important roles in the postnatal development of the CNS PMID: 18354028
    13. Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion. PMID: 18988673

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection. Cell projection, axon.
  • 蛋白家族：
    Sodium channel auxiliary subunit SCN1B (TC 8.A.17) family
  • 组织特异性：
    Detected in hippocampus CA3 bipolar neurons (at protein level). Detected in skeletal muscle.
  • 数据库链接：

    KEGG: mmu:20266

    STRING: 10090.ENSMUSP00000096148

    UniGene: Mm.1418