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  4. Recombinant Mouse Small conductance calcium-activated potassium channel protein 2 (Kcnn2)

Recombinant Mouse Small conductance calcium-activated potassium channel protein 2 (Kcnn2)

  • 中文名称：
    小鼠Kcnn2重组蛋白
  • 货号：
    CSB-CF012084MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Kcnn2
  • Uniprot No.：
  • 别名：
    Kcnn2; Sk2; Small conductance calcium-activated potassium channel protein 2; SK2; SKCa 2; SKCa2; KCa2.2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-574
  • 氨基酸序列
    MSSCRYNGGVMRPLSNLSSSRRNLQEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSA PEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRR ALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLI IVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSY APSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTL MTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMV PNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAAN VLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKT QNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQME NYDKHVSYNAERSRSSSRRRRSSSTAPPTSSESS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
  • 基因功能参考文献：
    1. SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake. PMID: 28282037
    2. Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT) neuronal excitability. PMID: 27874831
    3. SK2 is nuclear in primary neurons and, unexpectedly, overexpressed SK2 is neurotoxic in a dose-dependent manner.. We also found that SK2 is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease PMID: 28175299
    4. Thus, MPP2 is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2-containing channels. PMID: 26880549
    5. In addition to a well-established role for KCa2.x channels in migration, blockade of these channels was potently cytotoxic in breast cancer cell lines. PMID: 26454020
    6. Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias. PMID: 25605734
    7. enhanced SK2 channel control over NMDAR contributes to LTP impairment via increased PP2A activity following context dependent sensitization to morphine. PMID: 23735878
    8. This study reveleated that outer hair cells of SK2 knockout mice had few small efferent terminals. Synaptic cisterns were present, but smaller than those of wild-type littermates. PMID: 24122766
    9. SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats PMID: 23129791
    10. Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction. PMID: 23430260
    11. Virtually all Cav2.1 clusters are colocalized in Purkinje cells with two types of calcium-activated potassium channels, SK2 and BK. PMID: 23426693
    12. A developmental increase and gradient in SK2-containing channel surface expression is found that underlie the influence on neurotransmission. PMID: 22072564
    13. Sleep spindle occurrence is shaped by SK2-channel-mediated repetitive reticular thalamic nucleus neuron bursting & contributes to augmented NREMS consolidation & arousal threshold. PMID: 23035101
    14. Long-lasting plasticity of intrinsic excitability in dendrites results from changes in the gain of the SK2 channel regulatory mechanism of neurons. PMID: 22794265
    15. increasing SK2 channel activity, or preventing ischemia-induced loss of synaptic SK2 channels, are promising and novel approaches to neuroprotection following cerebral ischemia PMID: 21712833
    16. Results indicate that SK2-L directs synaptic SK2-containing channel expression and is important for normal synaptic signaling, plasticity and learning. PMID: 21602822
    17. Thus, SK2-sh as a downstream target of cytokines, provide a promising target for additional investigation regarding potential therapeutic intervention.(SH2-SH PROTEIN, MOUSE) PMID: 18624921
    18. Under basal conditions SK2 channels do not undergo rapid recycling and are present within the spine in a population of endosomes distinct from alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs). PMID: 20810893
    19. Because of the marked differential expression of SK2 channels in the heart, specific ligands for Ca2+-activated K+ currents may offer a unique therapeutic opportunity to modify atrial cells without interfering with ventricular myocytes PMID: 13679367
    20. Here we report the cloning, characterization, and expression of a complete SK2 cDNA from the mouse cochlea. The cDNAs of the mouse cochlea alpha9 and alpha10 acetylcholine receptors were also obtained, sequenced, and coexpressed with the SK2 channels. PMID: 14657188
    21. At the cellular level, SK2-like immunoreactivity is primarily localized to somatic and dendritic structures in mouse brain. PMID: 15234350
    22. the SK2 gene encodes two subunit proteins; native SK2-L subunits may preferentially partition into heteromeric channel complexes with other SK subunits PMID: 15797870
    23. SK2 channels regulate hippocampal synaptic plasticity and play a critical role in modulating mechanisms of learning and memory. PMID: 16467533
    24. SK2 overexpressers were not protected from acoustic injury PMID: 17267753
    25. These findings suggest a possible transcriptional cross talk between glucocorticoid receptors and NF-kappaB in the intronic promoter regulation of SK2-S channel gene transcription. PMID: 17396235
    26. SK2 channels have a functional influence on inner hair cells (IHC) during immature development. The altered Ca(2+) dependence of exocytosis in adult IHCs is likely to be a consequence of their disrupted action potential activity at immature stages. PMID: 17627990
    27. Overexpression of SK2 channels results in the shortening of the spontaneous action potentials of the atrioventricular node cells and an increase in the firing frequency PMID: 18096820
    28. SK2 gene is expressed in the bladder and that it is essential for the ability of SK channels to regulate urinary bladder smooth muscle contractility PMID: 18353877
    29. Transgenic mice overexpressing SK2 channels (SK2+/T mice) exhibit marked deficits in hippocampal memory and synaptic plasticity. PMID: 18385475
    30. describe a deletion in the 5' region of the Kcnn2 gene encoding the SK2 subunit in the neurological frissonnant (fri) mutant. The frissonnant mutant phenotype is characterized by constant rapid tremor and locomotor instability. PMID: 18604572
    31. SK2 channels are required both for expression of functional nAChRs, and for establishment and/or maintenance of efferent terminals in the cochlea. PMID: 18818242
    32. Results suggest a hierarchy of activity necessary to maintain early olivocochlear synapses at their targets, with SK2 serving an epistatic, upstream, role to the nicotinic acetylcholine receptors. PMID: 18848895
    33. The functional roles of SK2 channels in whole animals are discussed, and a possible link is provided between abnormalities in cardiac SK2 channels and cardiac arrhythmias. PMID: 19139040
    34. demonstrate that proper membrane localization of a small-conductance Ca(2+)-activated K(+) channel (SK2 or K(Ca)2.2) is dependent on its interacting protein, alpha-actinin2, a major F-actin crosslinking protein. PMID: 19815520
    35. SK2 null mice exhibit loss of nAChR-induced activity in mouse outer hair cells and efferent nerve fiber and synaptic boutons degeneration in the cochlea. SK2 is epistatic to the nAChR alpha10 gene as assessed in the SK2/alpha10 double null mouse. PMID: 18848895

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel KCNN family, KCa2.2/KCNN2 subfamily
  • 组织特异性：
    Expressed in atrial and ventricular myocytes with higher levels in atrial myocytes (at protein level). Highly expressed in brain, liver and colon with low levels in kidney and testis. In colon, detected in smooth muscle cells.
  • 数据库链接：

    KEGG: mmu:140492

    STRING: 10090.ENSMUSP00000067884

    UniGene: Mm.411614