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  4. Recombinant Mouse Receptor-type tyrosine-protein phosphatase epsilon (Ptpre)

Recombinant Mouse Receptor-type tyrosine-protein phosphatase epsilon (Ptpre)

  • 中文名称：
    小鼠Ptpre重组蛋白
  • 货号：
    CSB-CF019052MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Ptpre
  • Uniprot No.：
  • 别名：
    Ptpre; Ptpe; Receptor-type tyrosine-protein phosphatase epsilon; Protein-tyrosine phosphatase epsilon; R-PTP-epsilon
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-699
  • 氨基酸序列
    GQGNDTTPTESNWTSTTAGPPDPGASQPLLTWLLLPLLLLLFLLAAYFFRFRKQRKAVVSSNDKKMPNGILEEQEQQRVMLLSRSPSGPKKFFPIPVEHLEEEIRVRSADDCKRFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHCRVILSQVDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQRSATIVMLTNLKERKEEKCYQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIHPQLPDSCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPSHAGPIVVHCSAGVGRTGTFIVIDAMMDMIHSEQKVDVFEFVSRIRNQRPQMVQTDVQYTFIYQALLEYYLYGDTELDVSSLERHLQTLHSTATHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEFTDYINASFIDGYRQKDYFMATQGPLAHTVEDFWRMVWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGDITIEIKSDTLSEAISVRDFLVTFKQPLARQEEQVRMVRQFHFHGWPEVGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver. Plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function.; Acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake.; Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
  • 基因功能参考文献：
    1. GRB2 physically links cyt-PTPe with Src and enables cyt-PTPe to activate Src downstream of activated integrins in osteoclast-like cells. PMID: 25381250
    2. Multifaceted modulation of K+ channels by protein-tyrosine phosphatase epsilon tunes neuronal excitability. PMID: 22722941
    3. Integrin activation regulates cyt-PTPe via Src-dependent Y638 phosphorylation. cyt-PTPe affects osteoclast podosome stability by a feedback loop ensuring proper Src activation downstream of integrins, linking their signaling with Src activation. PMID: 19692574
    4. RPTPepsilon is a physiological activator of Src in Neu-induced mammary tumors. PMID: 12598528
    5. cyt-PTP epsilon is dimerized and phosphorylated in the absence of direct interaction between the PTP and extracellular molecules PMID: 12861030
    6. PTPepsilon as a phosphatase required for optimal structure, subcellular organization, and function of osteoclasts PMID: 14528021
    7. Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex. PMID: 14757526
    8. Protein tyrosine phosphatase epsilon activates Yes and Fyn in mammary tumor cells. PMID: 14980517
    9. Data show that association of protein tyrosine phosphatase epsilon with microtubules inhibits phosphatase activity and is regulated by the epidermal growth factor receptor. PMID: 17709387
    10. cytosolic PTPepsilon serves as another major candidate negative regulator of insulin receptor signaling in skeletal muscle PMID: 18006633
    11. Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling PMID: 18093973
    12. findings show that PTPe is expressed in erythrocytes & is involved in red cell signaling networks PMID: 18924107
    13. Data suggest that PTPepsilon negatively regulates FcepsilonRI-mediated signalling pathways and thus constitutes a novel target for ameliorating allergic conditions. PMID: 19508371

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin can induce translocation to the membrane.; [Isoform 3]: Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 4 subfamily
  • 组织特异性：
    Isoform 2 is expressed in the spleen and thymus (at protein level). Detected in fibroblasts, myeloid cells, macrophages, and T-cells but not in B-cell lines. Isoform 1 and isoform 2 are expressed predominantly in the brain, testes, and lungs, with lower l
  • 数据库链接：

    KEGG: mmu:19267

    STRING: 10090.ENSMUSP00000073616

    UniGene: Mm.945