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Recombinant Mouse Protein SCAI (Scai)

  • 中文名称：
    小鼠Scai重组蛋白
  • 货号：
    CSB-CF804009MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Scai
  • Uniprot No.：
  • 别名：
    Scai; Protein SCAI; Suppressor of cancer cell invasion protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-606
  • 氨基酸序列
    MVRGARQSQQPRSRLAPRLSGTVEKPPRKRKSRTEFTLKETMSSGGAEDDIPQGERKTVT DFCYLLDKSKQLFNGLRDLPQYGQKQWQSYFGRTFDVYTKLWKFQQQHRQVLDNRYGLKR WQIGEIASKIGQLYYHYYLRTSETSYLNEAFSFYSAIRQRSYYSQVNKEDRPELVVKKLR YYARFIVVCLLLNKMDVVKDLVKELSDEIEDYTHRFNTEDQVEWNLVLQEVAAFIEADPV MVLNDDNTIVITSNRLAETGAPLLEQGMIVGQLSLADALIIGNCNNQVKFSELTVDMFRM LQALEREPMNLASQMNKPGIQEPADKPTRRENPHKYLLYKPTFSQLYTFLAASFKELPAN SVLLIYLSATGVFPTGRSDGEGPYDFGGVLTNSNRDIINGDAIHKRNQSHKEMHCLHPGD LYPFTRKPLFIVVDSSNSVAYKNFTNLFGQPLVCLLSPTAYPKALQDQSQRGSLFTLFLN NPLMAFLFVSGLSSMRRGLWEKCQEYLRKINRDIAQLLTHSRSIDQAFLQFFGDEFLRLL LTRFVFCSATMRMHKAFRETRNYPESYPQLPRDETVENPHLQKHILELASILDVRNIFFE NSMDDY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.
  • 基因功能参考文献：
    1. SCAI (suppressor of cancer cell invasion) is identified as a 53BP1-interacting chromatin-associated protein that promotes the functionality of several DNA double-strand breaks repair pathways in mammalian cells. PMID: 27820601
    2. SCAI is a novel transcriptional cofactor that regulates epithelial-to-mesenchymal transition and renal fibrosis. PMID: 23178076
  • 亚细胞定位：
    Membrane; Single-pass membrane protein. Nucleus. Cytoplasm. Note=Nuclear localization is required for inhibition of MRTFA.
  • 蛋白家族：
    SCAI family
  • 组织特异性：
    Expressed in most tissues tested with higher expression levels in brain, spleen and thymus.
  • 数据库链接：

    KEGG: mmu:320271

    STRING: 10090.ENSMUSP00000037194

    UniGene: Mm.204836