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  4. Recombinant Mouse Potassium voltage-gated channel subfamily A member 3 (Kcna3)

Recombinant Mouse Potassium voltage-gated channel subfamily A member 3 (Kcna3)

  • 中文名称：
    小鼠Kcna3重组蛋白
  • 货号：
    CSB-CF012008MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Kcna3; Potassium voltage-gated channel subfamily A member 3; MK3; Voltage-gated potassium channel subunit Kv1.3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-528
  • 氨基酸序列
    MTVVPGDHLLEPEAAGGGGGDPPQGGCGSGGGGGGCDRYEPLPPALPAAGEQDCCGERVV INISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGG RIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYP ESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAPSG ASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTEL AERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFI GVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIA GVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKS EYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
  • 基因功能参考文献：
    1. Our data shed light on the putative role of Kv1.3 in weight gain and insulin-dependent responses contributing to knowledge about adipocyte physiology PMID: 29947924
    2. Data show that cereblon (CRBN) limits CD4(+) T-cell activation via epigenetic regulation of Kv1.3 potassium channel (Kv1.3) expression. PMID: 27439875
    3. Following differentiation with LPS or a combination of LPS and IFN-gamma microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa 3.1 and Kir currents, while microglia differentiated with IL-4 exhibited large Kir 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa 3.1 currents were generally low PMID: 27696527
    4. These studies reveal unexpected roles of Kv1.3 subunit-containing channels in the regulation of firing patterns of striatal cholinergic interneurons, which were thought to be largely dependent on KCa channels. PMID: 27568555
    5. the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 interaction. PMID: 27802162
    6. promotes B lymphocyte activation, proliferation and monocyte chemotaxis PMID: 26795234
    7. Changes in Kv1.3 subcellular distribution upon EGFR activation were due to Kv1.3 clathrin-dependent endocytosis, which targets the Kv1.3 channels to the lysosomal degradative pathway. PMID: 26542799
    8. Kv1.3 channel serves as a negative regulator of phagocytosis in macrophages and can be a potential target in the treatment of macrophage dysfunction PMID: 26354506
    9. concluded that Kv1.3 may stimulate macrophage migration through the activation of ERK. PMID: 26748289
    10. A compensatory upregulation of the potassium channels K2P3.1 and KV1.3 seems to counterbalance the deletion of K2P5.1. PMID: 26213925
    11. Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties PMID: 26150529
    12. A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation PMID: 24244345
    13. Our studies suggest thatKv1.3 plays a unique role in neuronal differentiation and/or survival of interneuron populations of the cerebral cortex PMID: 23821603
    14. Inhibition of NMDAR antagonists on the conductivity of Kv1.3 and KCa3.1 potassium channels was found. PMID: 24344200
    15. A significant increase of Kv1.3 protein levels was observed after LPS challenge, an effect that was blunted by e-LXA4. Kv1.3 is required for the attenuation of NF-kappaB activity. PMID: 24249731
    16. Results indicate the potential use of Kv1.3 blockers for the treatment of obesity and insulin resistance. PMID: 23729813
    17. Exert inhibitory effects on thymocyte Kv1.3-channel currents. PMID: 22978806
    18. Data indicate that ShK-K amide retained a high affinity for the voltage-gated potassium channel Kv1.3 channels (IC50 26 +/- 3 pM). PMID: 23063513
    19. findings suggest that pathways activated in Kv1.3-/- that increased energy expenditure and led to resistance to DIO are olfactory bulb dependent PMID: 22435906
    20. Our data demonstrate that Kv1.3 plays an important role in Ag-specific activation of CD4+ T cells during the course of experimental autoimmune encephalomyelitis PMID: 22581856
    21. the conserved upregulation of Kv1.3 on phenotypic modulation in several vascular beds makes this channel a good target to control unwanted vascular remodeling. PMID: 22383699
    22. Mitral cells of the olfactory bulb perform metabolic sensing and are disrupted by obesity at the level of the Kv1.3 ion channel PMID: 21966386
    23. KCNE2 influences blood-CSF anion flux by regulating KCNQ1 and KCNA3 in the choroid plexus epithelium. PMID: 21859894
    24. findings are not supportive of a role for Kv1.3 in the modulation of peripheral insulin sensitivity PMID: 21586699
    25. Kv1.3/TASK2 channels appear to be mainly responsible for regulatory volume decrease in murine T-lymphocytes. PMID: 21575593
    26. K(V)1.3 potassium channels are functional in proliferating mouse and human vascular smooth muscle cells and have positive effects on cell migration. Blockers of the channels may be useful as inhibitors of neointimal hyperplasia. PMID: 20884640
    27. The finding of a tonotopic gradient in presynaptic terminals suggests that Kv1.3 may regulate neurotransmitter release differentially in neurons that respond to different frequencies of sound. PMID: 20575068
    28. This study demonistrated that olfactory phenotype of Kv1.3-/- animals results in part from an enhancement of K(Na) currents. PMID: 20393063
    29. We conclude that Kv1.3 forms the Kv channel of the platelet and megakaryocyte, which sets the resting membrane potential. PMID: 20308249
    30. Kv1.3 currents increased in proliferating vascular smooth muscle cells and their selective blockade inhibits migration and proliferation. PMID: 20299686
    31. results indicate that Kv1.3 containing channels predominantly determined Kdr currents in activated microglia after status epilepticus PMID: 19707551
    32. the level of chloride current in Kv1.3-/- thymocytes was increased approximately 50-fold over that in wild-type cells PMID: 12878608
    33. macrophage cells expressed outward delayed and inwardly rectifying K+ currents mainly mediated by Kv1.3 and Kir2.1 channels PMID: 12923194
    34. These data suggest that Kv1.3 plays a far more reaching role in signal transduction, development, and olfactory coding than that of the classically defined role of a potassium channel-to shape excitability by influencing membrane potential. PMID: 14766178
    35. Kv1.3 gene deletion and channel inhibition increase peripheral insulin sensitivity in vivo and affects insulin stimulated glucose uptake. PMID: 14981264
    36. Kv1.3 and Kir2.1 expression was impaired in brain during cancer cachexia. PMID: 15304346
    37. Results indicate that the increase in insulin sensitivity observed in association with inhibition of Kv1.3 channels is mediated by an increase in GLUT4 protein at the plasma membrane, largely through a Ca(2+)-dependent process. PMID: 16403947
    38. Kv1.5 co-associates with Kv1.3, generating functional heterotetramers in macrophages PMID: 17038323
    39. Kv1.3-based treatments to alter physiological responses, such as proliferation and activation, are impaired by Kv1.5 expression PMID: 17157812
    40. Deletion of voltage-gated channel( kv1.3) affects glomerular refinement and odorant receptor expression in the mouse olfactory system PMID: 18022950
    41. implicate the traffic and localization of Kv1.3/Kv1.5 heteromers in the complex regulation of immune system cells PMID: 18218624
    42. Gene-targeted deletion of Kv1.3 can reduce adiposity and total body weight in a genetic model of obesity by increasing both locomotor activity and mass-specific metabolism. PMID: 18542083
    43. These findings suggest that Bax mediates cytochrome c release and mitochondrial depolarization in lymphocytes, at least in part, via its interaction with mitochondrial Kv1.3. PMID: 18818304
    44. study reports co-localization of adaptor proteins nShc & Grb10, with Kv1.3 channel in the olfactory bulb neural lamina; BDNF-induced current suppression of the Kv1.3 channel was prevented by both nShc and Grb10 PMID: 19166614
    45. segregation of Kv1.3 channels into the immunological synapse modifies the gating properties of the channels. PMID: 19477198

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.3/KCNA3 sub-subfamily
  • 数据库链接：

    KEGG: mmu:16491

    STRING: 10090.ENSMUSP00000050680

    UniGene: Mm.30640