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  4. Recombinant Mouse Neuronal acetylcholine receptor subunit beta-4 (Chrnb4)

Recombinant Mouse Neuronal acetylcholine receptor subunit beta-4 (Chrnb4)

  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit beta-4(Chrnb4)
  • 货号：
    CSB-CF819188MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Chrnb4
  • Uniprot No.：
  • 别名：
    Chrnb4; Acrb4; Neuronal acetylcholine receptor subunit beta-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    21-495
  • 氨基酸序列
    RLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNEREQIMTTSIWL KQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRSNGSI QWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAIMDDFTPSGEW DIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCG EKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHH RSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSPARVPHSSQLHLTTAEATSTSALGPS SPSNLYGNSMYFVNPVPATPKSAVSSHTAGLPRDARLRSSGRFRQDLQEALEGVSFIAQH LESDDRDQSVIEDWKFVAMVVDRLFLWVFVIVCILGTMGLFLPPLFQIHAPSKGL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能参考文献：
    1. These findings suggest that beta4* nAChRs in the interpeduncular nucleus have a role in maintaining nicotine intravenous self-administration. PMID: 26585290
    2. Data suggest that the nicotinic acetylcholine receptor beta4 subunit (beta4 subunit) is not involved in ethanol responses. PMID: 28381286
    3. MAFA controls autonomic nervous system-mediated insulin secretion by activating the transcription of nicotinic (ChrnB2 and ChrnB4) receptor genes, which is impaired in type 2 diabetes. PMID: 26904947
    4. The alpha3beta4* nicotinic ACh receptor subtype mediates physical dependence to morphine PMID: 24750073
    5. nAChRs that contain the beta4 subunit are important for social behaviors. PMID: 23042983
    6. Downregulation of nAChR subunit and PSD-93 expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries. PMID: 24049141
    7. findings suggest an important role for the a3b4* nAChR subtype in nicotine reward and physical aspects of the nicotine withdrawal syndrome. PMID: 23416040
    8. Chrnb4 is involved in anxiety- and perhaps depression-like behaviors and contribute to the analgesic effects of nicotine. PMID: 22573727
    9. mutation depressed fusion rates of alpha4beta4 receptor-containing vesicles with the plasma membrane by approximately 2-fold, with only a small decrease in the number of nAChRs per vesicle. The mutation also decreased the number of endoplasmic reticulum exit sites PMID: 21768117
    10. At higher doses, varenicline is an agonist of Chrnb4 producing physiological changes in mice. PMID: 22241831
    11. the present results indicate an important role for Chrna7 and Chrnb4 -containing nicotinic acetylcholine receptors in the anhedonic or somatic signs of nicotine withdrawal PMID: 22009521
    12. A mechanistic model provides sharpening of mitral cell receptive fields by activation of the alpha3beta4 subtype of nicotinic receptor, which could aid in odor discrimination and perceptual learning. PMID: 22378897
    13. This study demonstrated thatalpha3beta4alpha5 receptor-mediated mechanisms contributing to nicotine consumption, and identifies the medial habenula as a critical element in the circuitry controlling nicotine-dependent phenotypes. PMID: 21555077
    14. CA box is critical for beta4 promoter activity in vivo. PMID: 20696214
    15. Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles. PMID: 20496163
    16. beta 4 subunits are important components of nAChRs in autonomic ganglia. Deficiency of beta 4 subunits altered ion channel properties, conductance, and sensitivity and affinity of receptors to agonists and antagonists, affecting ganglionic transmission. PMID: 12606764
    17. Tests on beta4-knockout mice revealed beta4-containing nAChRs influence behavioral responses during anxiety-related tests, and that this effect depends on the type of anxiety-provoking experience PMID: 12867510
    18. Immunohistochemical analysis of nAChRbeta4 in the mouse brain suggests an extensive and potentially diverse role for this subunit in both excitatory and inhibitory neurotransmission. PMID: 14681928
    19. There is a a major role for beta4-containing nicotinic acetylcholine receptors in the appearance of nicotine withdrawal symptoms. PMID: 15537871
    20. The involvement of the beta4 nAChR subunit in both core body temperature homeostasis and nicotine-elicited thermo-alterations in mice. PMID: 15925141

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Beta-4/CHRNB4 sub-subfamily
  • 组织特异性：
    Predominantly expressed by immature T-cells in the thymus.
  • 数据库链接：

    KEGG: mmu:108015

    STRING: 10090.ENSMUSP00000034854

    UniGene: Mm.32694