Recombinant Mouse Mitochondrial uncoupling protein 3 (Ucp3)

1. Our findings, focusing on energy balance, provide a mechanistic understanding of the promising effect of early insulin initiation on lipotoxicity. Insulin, by recovering UCP3 activity, alleviated energy surfeit and potentiated AMPK-mediated lipid homeostasis in skeletal muscle cells following exposure to PA and in gastrocnemius of mice fed HFD. PMID: 29039450
2. Findings indicate that while heat-induced reduction in uncoupling proteins-3 improves mitochondrial efficiency in vitro, this is not translated to in vivo improvement of exercise economy at 1600 m or 4350 m. PMID: 28174343
3. UCP3 can be fully inhibited by all adenine nucleotides tested and IC50 increases with a decrease in PN-phosphorylation. Conserved arginines in the PN-binding pocket are involved in the inhibition of UCP1 and UCP3 to different extents. Fatty acids compete only with ATP bound to UCP3. UCP3 has adapted to fulfill a different role and possibly another transport function in brown adipose tissue, vs highly homologous UCP1. PMID: 29212043
4. our study provides evidence that the genetic risk factors for healthy aging differ in males and females, as expected from the differences in the phenotypes associated with healthy aging between the two sexes. It also has implications for how mitochondrial function changes during aging. PMID: 26965008
5. The results indicate that mitochondrial UCP3 activity affects metabolism well beyond fatty acid oxidation, regulating biochemical pathways associated with amino acid metabolism and redox status. PMID: 27871066
6. Gene expression data revealed that 1, 4 or 8h of hypoxia results in temporal changes in various transcriptional genes regulating mitochondrial function and a time-dependent progressive increase in the expression of the mitochondrial uncoupling protein 3 (UCP-3) with concomitant changes in genes encoding sarcoplasmic reticulum calcium release proteins. PMID: 26549555
7. our study supports an essential role for UCP3 in modulating cardiac mCa2+ uptake via regulation of mCa1 single-channel activity. PMID: 27371160
8. Intriguingly, ectopic expression of constitutively active estrogen receptor alpha decreased UCP3 level and increased cellular ATP content in differentiated myoblastic C2C12 cells. Overall, the present study suggests that estrogen plays a critical role in the regulation of energy expenditure and exercise endurance in female. PMID: 27983991
9. We found increased mRNA expression of PDK4 and UCP3, which are known to be upregulated after exercise and regulated by PGC-1alpha after lactate administration. PMID: 27218871
10. suggest that VD3/VDR inhibits weight gain by activating UCP3 in the muscles. PMID: 27473111
11. the protective effect of PPARalpha activation against cardiac ischemia-reperfusion injury in terms of the expression of uncoupling protein (UCP), was investigated. PMID: 26770648
12. low 4-Hydroxy-2-nonenal (HNE) doses activate Nrf2 in cardiomyocytes and provide the first evidence of Nrf2 binding to the Ucp3 promoter in response to HNE, leading to increased protein expression PMID: 25843654
13. The hydrophilic sequences within loop 2, and the matrix-localized hydrophilic domain of UCP3, were necessary for binding to Hax-1 at the C-terminal domain, adjacent to the mitochondrial inner membrane. PMID: 26915802
14. UCP3 overexpression limits keratinocyte proliferation and tumorigenesis through inhibition of Akt. PMID: 26310111
15. Ischemia/reperfusion also increased UCP3 transcription, indicating potential for greater uncoupling. PMID: 25450611
16. Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress. PMID: 23597505
17. Data indicated that Trim30 and Ucp3 play pivotal roles in energy balance and glucose homeostasis and might be used as genetic markers to represent the stage of obesity during the early and late stages of adipose tissue development, respectively. PMID: 25895476
18. In a mice model of permanent coronary occlusion, UCP3 deficiency results in a metabolic shift that favored glycolytic metabolism and increased FDG uptake in remote areas. PMID: 25103673
19. These results are consistent with the conclusions that circulating acylcarnitines could be used as a marker of incomplete muscle FAO and that UCP3 is a potential target for the treatment of prevalent metabolic diseases in which muscle FAO is affected. PMID: 23825224
20. Our data indicate that ucp3 levels regulate reactive oxygen species levels and cell survival during hypoxia, modulating infarct size in the ischemic heart PMID: 23688674
21. UCP3 plays a critical role in cardioprotection against ischemia-reperfusion injury. PMID: 23457013
22. Grx2 deactivates UCP3 by glutathionylation. PMID: 23335511
23. Studies show that although UCP3 may mediate mitochondrial uncoupling and reduced CE after HF feeding, it does not mediate uncoupling in leptin-deficient states. PMID: 22912419
24. STC1 activates a novel anti-oxidant pathway in cardiac myocytes through induction of UCP3 PMID: 22693564
25. UCP3 may have a role in the protection of mitochondria against lipid-induced mitochondrial dysfunction, but only after long-term exposure to high-fat PMID: 22115550
26. lack of UCP3 had no apparent effect on basal oxygen consumption of thymocytes or splenocytes or on oxygen consumption due to mitochondrial proton leak PMID: 21689632
27. examined oxidative stress by quantifying 4-hydroxynonenal protein adducts and protein carbonyls in the mitochondria-but did not observe any protective effect of UCP3 PMID: 21565164
28. Deficiency in UCP3 resulted in a metabolic shift that favoured anaerobic glycolytic metabolism, increased glucose uptake and increased sensitivity to oxidative challenge. PMID: 21554247
29. The native UCP3 actively lowers the rate of ROS production in isolated energized skeletal muscle mitochondria, and UCP3 can affect ROS production through a membrane potential-independent mechanism. PMID: 20493945
30. no evidence for an involvement of UCP3 in basal, fatty-acid- or superoxide-stimulated oxygen consumption or in GDP sensitivity PMID: 20227385
31. UCP3 can minimize the induction of the adenine nucleotide translocase-mediated 'energy-wasting' process during Calorie restriction (CR). PMID: 20206124
32. UCP3 is involved both in mediating the translocation of lipid hydroperoxide (LOOH) across the mitochondrial inner membrane and in LOOH-dependent mitochondrial uncoupling PMID: 20363757
33. UCP3 was degraded in mitochondria isolated from rat skeletal muscle or brown adipose tissue with a half-life of 0.5-4 h and the turnover is proteasome dependent. PMID: 19954423
34. excess recovery heat production by isolated muscles from mice overexpressing uncoupling protein-3 PMID: 12096064
35. Mitochondria from UCP3-underexpressing mice had higher levels of oxidative damage than wild-type controls, suggesting that UCP3 functions as part of the antioxidant defences of the cell PMID: 12193161
36. expression of UCP3 mRNA was dependent on human muscle differentiation PMID: 12351640
37. mice deficient in UCP-3 (for 'uncoupling protein-3') have a diminished thermogenic response to the drug MDMA (3,4-methylenedioxymethamphetamine, nicknamed 'ecstasy') and so are protected against this dangerously toxic effect PMID: 14647371
38. Using transgsenic mice,an 18-fold increase of UCP3 mRNA can be attained, suggesting that UCP3 has therapeutic potential in the treatment of obesity. PMID: 14673524
39. Consistent with increased energy expenditure, C75 treatment caused greater weight loss than pair-fed controls and increased expression of skeletal muscle UCP-3 mRNA. PMID: 15063757
40. UCP3 gene transcription is activated by thyroid hormone treatment in vivo, and this activation is mediated by a TRE (thyroid hormone response element) in the proximal promoter region PMID: 15496137
41. findings support the hypothesized role for Uncoupling protein 3 in facilitating fatty acid oxidation in muscle PMID: 15814607
42. UCP3 modulates reactive oxygen species production in response to an oxidative stress. PMID: 15922330
43. UCP3 attenuates endogenous radical production by the mitochondrial electron transport chain at high protonmotive force. PMID: 16084485
44. Overexpression of UCP3 gene in mouse myotube cell culture leads to significant activation of different proteolytic systems involved in muscle myofibrillar protein breakdown. These results suggest possible relation involved in muscle wasting during cancer. PMID: 16337086
45. upon high-fat feeding, intramuscular triacylglycerol levels were 50% lower in UCP3-/- mice; succinate dehydrogenase activity, and total protein content of the muscle fatty acid transporter FAT/CD36 were similar between UCP3-/- and UCP3+/+ mice. PMID: 16455084
46. PPARalpha-dependent regulation is required for appropriate gene regulation of UCP3 PMID: 16857752
47. Apelin treatment increased mRNA expression of UCP3 in skeletal muscle. PMID: 17347313
48. increasing mitochondrial uncoupling in skeletal muscle may be an excellent therapeutic target for type 2 diabetes mellitus PMID: 17571165
49. Induction of Ucp3 suppresses mitochondrial oxidant emission during fatty acid-supported respiration. PMID: 17761668
50. SIRT1 acts as a major repressor of ucp3 gene expression in response to glucocorticoids. PMID: 17884810

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KEGG: mmu:22229

STRING: 10090.ENSMUSP00000032958

UniGene: Mm.6254