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  4. Recombinant Mouse Lysosome membrane protein 2 (Scarb2)

Recombinant Mouse Lysosome membrane protein 2 (Scarb2)

  • 中文名称：
    小鼠Scarb2重组蛋白
  • 货号：
    CSB-CF020768MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Scarb2
  • Uniprot No.：
  • 别名：
    Scarb2; Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein; LGP85; Lysosome membrane protein II; LIMP II; Scavenger receptor class B member 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-478
  • 氨基酸序列
    GRCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFNSWEKPPLPVYIQFYFFNVTNPEEILQGEIPLLEEVGPYTYRELRNKANIQFGENGTTISAVTNKAYVFERNQSVGDPNVDLIRTINIPLLTVVDLAQLTLLRELIEAMLKAYQQKLFVIHTVHELLWGYKDEILSLVHIFKPDVSPNFGLFYERNGTNDGEYVFLTGEDNYLNFSKIVEWNGKTSLDWWTTDTCNMINGTDGDSFHPLISKDEVLYLFPSDLCRSVHITFSSFENVEGLPAFRYKVPAEILANTSENAGFCIPEGNCMDSGVLNISICKNGAPIIMSFPHFYQADEKFVSAIKGMHPNKEEHESFVDINPLTGIILRGAKRFQINTYVRKLDDFVETGDIRTMVFPVMYLNESVLIDKETANQLKSVINTTLVVTNIPYIIMALGVFFGLVFTWLACRGQGSMDEGTADERAPLIRT
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.
  • 基因功能参考文献：
    1. LIMP-2 facilitates transport of phospholipids into murine fibroblasts, with a strong substrate preference for phosphatidylserine. PMID: 29199275
    2. The findings identify SR-BII as a functional SAA receptor that mediates SAA uptake and contributes to its proinflammatory signaling via the MAPK-mediated signaling pathways. PMID: 28423002
    3. AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo PMID: 26907692
    4. Heterologous expression of the luminal domain of LIMP-2 in wild-type cells. PMID: 26219725
    5. In LIMP-2-deficient brains a significant reduction in GC activity led to lipid storage, disturbed autophagic/lysosomal function, and alpha-synuclein accumulation. PMID: 25316793
    6. absence of Limp-2 reduces inflammation in experimental crescentic glomerulonephritis with decreased macrophage and T-cell infiltration in the kidney. PMID: 24394995
    7. Limp-2 deficiency leads to a minor increase in circulating renin. Limp-2, however, is not required for acute or chronic stimulation of renin release. PMID: 23635510
    8. The SR-BII is involved in cholesterol ester uptake for steroidogenesis and spermatogenesis in the testis. PMID: 22988039
    9. The residues between 144 and 151 are critical for SCARB2 binding to VP1 of EV71 and seven residues from the human receptor could convert murine SCARB2, an otherwise inefficient receptor, to an efficient receptor for EV71 viral infection. PMID: 22219187
    10. The data suggest that tubular proteinuria in Limp-2(-/-) mice is due to failure of endosomes containing reabsorbed proteins to fuse with lysosomes in the proximal tubule of the kidney. Failure of proteolysis is a novel mechanism for tubular proteinuria. PMID: 21429972
    11. The coiled-coil structure of LIMP-2 is required for its interaction with beta-glucocerebrosidase. PMID: 19933215
    12. CD36 is not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ dendritic cells. PMID: 12055214
    13. CD36 is differentially expressed by CD8+ splenic dendritic cells but is not required for cross-presentation in vivo. PMID: 12055215
    14. Overexpression of LGP85 causes an enlargement of early endosomes and late endosomes/lysosomes. LGP85 may participate in reorganizing the endosomal/lysosomal compartments. PMID: 12356916
    15. SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence PMID: 12376530
    16. LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice PMID: 12620969
    17. Our findings suggest an important role for LIMP2 in the control of the localization and the level of apically expressed membrane proteins such as KCNQ1, KCNE1 and megalin in the stria vascularis. PMID: 16901941
    18. Peritoneal macrophages isolated from SR-BI/BII-knockout mice demonstrated a 30% decrease in bacterial uptake when compared with macrophages from normal mice. PMID: 17071747
    19. Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy. PMID: 17485520
    20. These data support a role for LIMP-2 as the mannose-6-phosphate-independent trafficking receptor for beta-glucocerebrosidase. PMID: 18022370

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  • 亚细胞定位：
    Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    CD36 family
  • 组织特异性：
    Detected in the extracts of brain, heart, lung, liver and kidney.
  • 数据库链接：

    KEGG: mmu:12492

    STRING: 10090.ENSMUSP00000031377

    UniGene: Mm.297964