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  4. Recombinant Mouse Gap junction gamma-1 protein (Gjc1)

Recombinant Mouse Gap junction gamma-1 protein (Gjc1)

  • 中文名称：
    小鼠Gjc1重组蛋白
  • 货号：
    CSB-CF009458MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Gjc1
  • Uniprot No.：
  • 别名：
    Gjc1; Cxn-45; Gja7; Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-396
  • 氨基酸序列
    MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR WKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQ LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG LCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQ YTELSNAKIAYKQNKANIAQEQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQN NPHGPREKKAKVGSKSGSNKSSISSKSGDGKTSVWI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 基因功能参考文献：
    1. Punctate labelling of Cx45 was faint in the cerebellar cortex molecular layer of wild-type mice and was increased in intensity in mice with Cx36 gene ablation. The vast majority of Cx36-puncta co-localized with Cx45-puncta, which in turn was associated with the scaffolding protein zonula occludens-1. PMID: 28561933
    2. connexin45 carboxyl-terminal domain structure and interactions with molecular partners PMID: 24853747
    3. The ablation of Cx45 reduced neuronal loss by approximately 50% under ischemic insult. PMID: 25100592
    4. This study demonstrated using Cx45-eGFP transgenic mice that Cx45-eGFP cells are distributed along the rostrocaudal extent of the spinal cord with expression mainly restricted to the grey matter of dorsal laminae I-III PMID: 22638825
    5. Connexins 36 and 45 could be involved in supporting Leydig cell steroidogenesis. PMID: 23458200
    6. Suggest critical role for Cx45 in the regulation of endothelial-induced mesenchymal cell differentiation towards a mural cell phenotype. PMID: 23220276
    7. Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone. PMID: 23169657
    8. Cx45 is required for optimal impulse propagation in the atrioventricular node; cardiomyocyte-directed deficiencies of Cx45 in mice lead to embryonic lethality attributable to morphological and functional cardiovascular defects. PMID: 22982984
    9. Cx45 is physiologically expressed in vascular smooth muscle PMID: 22848755
    10. The cx45 strongly modulate the firing pattern of individual RGCs, ensuring strongly correlated firing between nearby RGCs and normal patterning of retinogeniculate projections. PMID: 21734291
    11. Data suggest that Cx45 is expressed on OFF bipolar cell dendrites, presumably forming gap junctions with cells of the same type, and on OFF bipolar cell axon terminals, presumably forming heterologous gap junctions with other retinal neurons. PMID: 21192077
    12. Data suggest that Cx45 and Cx36 have similar functions in the retina, whereas Cx45 fulfills special functions in the developing heart that cannot be compensated by Cx36. PMID: 20930146
    13. The neuron-directed deletion of Cx45 impaired one-trial novel object recognition and altered kainate-induced gamma-oscillations possibly via the disruption of inter-neuronal gap junctional communication in the hippocampus or perirhinal cortex. PMID: 20471991
    14. data suggests that connexin 45 and ZO-1 directly interact in osteoblastic cells (ROS/Cx45) PMID: 12064590
    15. Cx40 knock-in Cx45 mice were generated to explore the ability of Cx45 to replace Cx40 function in cardiac electrical conduction. PMID: 14630724
    16. Connexin45 is localized to vascular tissue of pancreatic islets. PMID: 14980497
    17. play a role in the inner ear vascular system development PMID: 14986102
    18. Cx43 and Cx45 form homomeric-homotypic, homomeric-heterotypic channels as well as heteromeric-homotypic and heteromeric-heterotypic channels. PMID: 15048573
    19. Expression of Cx45 is up-regulated during skeletal muscle regeneration. PMID: 15601660
    20. These data suggest that Cx45 participates in the formation of functional heterotypic electrical synapses between two types of retinal neurons that make up the major rod pathway. PMID: 15659592
    21. Cx45 was found in some ON bipolar cells, but RT-PCR showed Cx36 and not Cx45 to be expressed by the bipolar cells. Some of the remaining GFP-negative bipolar cells expressed Cx45 but not Cx36. PMID: 16014731
    22. Connexin45 mediates gap junctional coupling of bistratified ganglion cells in the mouse retina. PMID: 16041717
    23. Increased myocardial expression of Cx45 results in remodeling of intercellular coupling and greater susceptibility to ventricular arrhythmias in vivo. PMID: 16126808
    24. These morphological data suggest that Connexin45 may play a modifying role in widely distributed, coupled neurons of the olivocerebellar system, but that it is not essential for the creation of its neuronal gap junctions. PMID: 16435305
    25. Our results provide direct evidence for heterotypic gap junctions composed of Cx45 between AII amacrine and certain types of ON cone bipolar cells. PMID: 17004931
    26. Cx45 was seen ubiquitously distributed throughout the retina in cells undergoing proliferation and differentiation, as well in differentiated neurons. In adult retina, this protein had a more restricted distribution both in neurons and glial cells. PMID: 17029293
    27. Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure. PMID: 18579650
    28. CAR mediates Cnx45 localization in the murine heart. PMID: 18636119
    29. Increased expression in the failing ventricle contributes to decreased gap junction size. PMID: 18649189
    30. These data document that in Cx45-expressing neurons of IPL, Cx45 is almost always accompanied by Cx36, forming "bihomotypic" gap junctions, with Cx45 structurally coupling to Cx45 and Cx36 coupling to Cx36. PMID: 18815262
    31. The Cx45eGFP transgene could not rescue embryonic lethality of Cx45-deficient mice. PMID: 19473725

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Connexin family, Gamma-type subfamily
  • 数据库链接：

    KEGG: mmu:14615

    STRING: 10090.ENSMUSP00000066901

    UniGene: Mm.390369