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  4. Recombinant Mouse Gap junction alpha-4 protein (Gja4)

Recombinant Mouse Gap junction alpha-4 protein (Gja4)

  • 中文名称：
    小鼠Gja4重组蛋白
  • 货号：
    CSB-CF009447MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Gja4
  • Uniprot No.：
  • 别名：
    Gja4; Cxn-37; Gap junction alpha-4 protein; Connexin-37; Cx37
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-333
  • 氨基酸序列
    GDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGC TNVCYDQAFPISHIRYWVLQFLFVSTPTLIYLGHVIYLSRREERLRQKEGELRALPSKDL HVERALAAIEHQMAKISVAEDGRLRIRGALMGTYVVSVLCKSVLEAGFLYGQWRLYGWTM EPVFVCQRAPCPHIVDCYVSRPTEKTIFIIFMLVVGVISLVLNLLELVHLLCRCVSREIK ARRDHDARPAQGSASDPYPEQVFFYLPMGEGPSSPPCPTYNGLSSTEQNWANLTTEERLT SSRPPPFVNTAPQGGRKSPSRPNSSASKKQYV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 基因功能参考文献：
    1. Diet-induced hyperhomocysteinemia enhanced myoendothelial feedback, and increased Cx37 and IK1 expression may contribute. nNOS or iNOS did not upregulate to compensate for decreased eNOS, and they had little involvement in vasomotor function. PMID: 28857417
    2. The presence of Cx37 in the media layer of injured arteries restrains vascular smooth muscle cell proliferation and limits the development of intimal hyperplasia, presumably by interfering with the pro-proliferative effect of Cx43 and the Akt pathway. PMID: 28449099
    3. altered profile of the bone matrix components in Cx37-deficient mice acts in favor of higher resistance to fracture in long bones. PMID: 28096061
    4. NO controls the calcium signal propagation through Cx37-containing gap junctions. The tyrosine phosphatase SHP-2 is the essential mediator and NO target. PMID: 29025706
    5. Cx37 deletion increased the size of atherosclerotic lesions in oscillatory shear stress regions and abrogated the development of a stable plaque phenotype under OSS in ApoE(-/-) mice PMID: 26342936
    6. Cx37 is more markedly involved in basal NO release, release of cyclooxygenase products and the regulation of the sensitivity for Acetylcholine as compared to Cx40. PMID: 26198171
    7. The data suggest that the P2Y2/4 receptor activation elicits blood pressure responses via distinct mechanisms involving KCa3.1 and Cx37. PMID: 25545736
    8. Endothelial connexin 40, but not connexin 37, is implicated in resistance of the heart to ischaemia/reperfusion injury by activation of the CD73 pathway PMID: 24639196
    9. Cx37 is required for osteoclast differentiation and fusion, and its absence leads to arrested osteoclast maturation and high bone mass in mice. PMID: 24509854
    10. Cx37, a protein involved in cell-cell communication, is one of only a few proteins identified so far as critical for the development or maintenance of venous valves. PMID: 23142761
    11. The effect of shear stress on Cx37 expression may contribute to the synchronization of ECs and participate in the protective effect of HLSS. PMID: 22659288
    12. We report the presence of connexins in platelets, notably connexin37, and that the formation of gap junctions within platelet thrombi is required for the control of clot retraction. PMID: 22528526
    13. Cx40 is required for, and cx37 limits, postischemic hindlimb perfusion, survival and recovery. PMID: 21986401
    14. Results are consistent with Cx37 exerting a growth-suppressive effect in the vasculature that limits embryonic vasculogenesis as well as arteriogenic and angiogenic responses to ischemic injury in the adult animal. PMID: 21856908
    15. We propose that the establishment of gap junctional communication between Cx37-expressing platelets provides a mechanism to limit thrombus propensity. PMID: 21810657
    16. Renal epithelia express Cx37 in their basolateral membranes. PMID: 19828678
    17. Cx40-deficient endothelial cells upregulate and redistribute Cx37 as a molecular adaptation to the lack of Cx40 PMID: 12011587
    18. endothelial gap junction protein connexin 37 and connexin 40-mediated communication in the development and/or functional maintenance of segments of the mouse vasculature. PMID: 12435353
    19. Cx37 and Cx40 are the only functional connexins expressed in mouse aortic endothelium and are collectively crucial for endothelial communication and are codependent on each other for optimal expression in vascular endothelium PMID: 12697838
    20. Cx37 and Cx40 are collectively critical for endothelial communication and provide evidence of an important role for gap junctions in vascular development. PMID: 14681045
    21. Recent large Japanese case-control studies identified connexin-37 (GJA-4), plasminogen activator inhibitor-1 (PAI-1), and stromelysin-1 (MMP-3) polymorphisms as risk factors for myocardial infarction. PMID: 15234427
    22. Localization and expression of Cx37 in ovarian mouse follicles of different developmental stages. PMID: 15836950
    23. Mouse oocytes must express connexin37 for communication with granulosa cells, a requirement for oogenesis. PMID: 16254245
    24. Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells. PMID: 18753315
    25. Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction. PMID: 18790841
    26. These data determine temporal gene expression of Cx37 in oocytes from follicules at different stages and indicate that the gene expression level of Cx37 in oocytes could be evaluated as a criterion to the regulatory mechanism of Cx37 in an in vitro model. PMID: 19222873
    27. we suggest that Cx37 deficiency alters the global differential gene expression profiles in young mice towards a pro-inflammatory phenotype, which are then further influenced in advanced atherosclerosis. PMID: 19345950
    28. We conclude that nitric oxide-induced reduction of electrical coupling between microvascular endothelial cells depends on Cx37 PMID: 19429814
    29. Cx37 is not essential for normal development and function of renin-producing cells PMID: 19672618

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Connexin family, Alpha-type (group II) subfamily
  • 组织特异性：
    Highly expressed in lung.
  • 数据库链接：

    KEGG: mmu:14612

    STRING: 10090.ENSMUSP00000062320

    UniGene: Mm.24615