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Recombinant Mouse Fatty acyl-CoA reductase 2 (Far2)

  • 中文名称：
    小鼠Far2重组蛋白
  • 货号：
    CSB-CF745868MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Far2; Fatty acyl-CoA reductase 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-515
  • 氨基酸序列
    MSMIAAFYSNKSILITGATGFLGKVLMEKLFRTSPHLKVIYILVRPKSGQTLQERVFQIL NSKLFEKVKEVCPNVHEKIRPISADLNQRDFAISKEDVQELLSCTNIIFHCAATVRFDAH LREAVQLNVTATQQLLLMASQMPKLEAFIHISTAFSNCNLSHIDEVIYPCPVEPRKIIDS MEWLDDSIIEEITPKLIGDRPNTYTYTKALGEIVVQQESGNLNVAIVRPSIVGATWQEPF PGWVDNLNGPSGLIIATGKGFLRSIKATPMAVADVIPVDTVVNLTIAVGWYTAVHRPKST LIYHSTSGNLNPCNWYKMGLQVLATIEKIPFESAFRRPNADFTTSNFTTHYWNTVSHRVP AIIYDFYLRLTGRKPRMLKLMNRLLKTISMLEYFINHSWEWSTNNTEMLLSELSPEDQRV FNFDVRQLNWLEYIENYVLGVKKYLLKEDLAGIPKAKQHLRRLRNIHYLFNTALFLIIWR LLIARSQMARNVWFFIVSFCYKFISYFRASSTLKV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates.
  • 基因功能参考文献：
    1. Mouse strains with mesangial matrix expansion contain a 9-bp sequence in the 5' untranslated region of Far2 that is absent in most of the strains without it. PMID: 24009241
    2. fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids PMID: 15220348
    3. wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes PMID: 15220349
  • 亚细胞定位：
    Peroxisome membrane; Single-pass membrane protein.
  • 蛋白家族：
    Fatty acyl-CoA reductase family
  • 组织特异性：
    Specifically expressed in the meibomian glands of the eyelid and the sebaceous glands of the skin. Also expressed in the brain where large quantities of ether lipids are synthesized.
  • 数据库链接：

    KEGG: mmu:330450

    STRING: 10090.ENSMUSP00000107234

    UniGene: Mm.447274