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  4. Recombinant Mouse Elongation of very long chain fatty acids protein 6 (Elovl6)

Recombinant Mouse Elongation of very long chain fatty acids protein 6 (Elovl6)

  • 中文名称：
    小鼠Elovl6重组蛋白
  • 货号：
    CSB-CF856352MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Elovl6
  • Uniprot No.：
  • 别名：
    Elovl6; Face; Lce; Masr; Elongation of very long chain fatty acids protein 6; 3-keto acyl-CoA synthase Elovl6; ELOVL fatty acid elongase 6; ELOVL FA elongase 6; Fatty acyl-CoA elongase; Long chain fatty acid elongase; Myelin-associated SUR4 protein; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-CoA synthase 6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-267
  • 氨基酸序列
    MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELR KPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSK APELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSY YALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFNWMQHDNDQCYSHFQNIFWSSLM YLSYLVLFCHFFFEAYIGKVKKATKAE
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
  • 基因功能参考文献：
    1. Elovl6 is a fundamental factor linking dysregulated lipid metabolism to beta-cell dysfunction, islet inflammation, and beta-cell apoptosis in T2D, highlighting oleate as the potential culprit of beta-cell lipotoxicity. PMID: 28461456
    2. data suggest that Elovl6 plays a critical role for proper development of embryonic growth plate PMID: 27467521
    3. the synergistic action of ChREBP and SREBP-1c is necessary for the maximal induction of Elovl6 expression in the liver. PMID: 27524233
    4. These findings suggest that Elovl6-mediated changes in hepatic FA composition, especially oleic acid (C18:1n-9), control handling of hepatic cholesterol and BA, which protects against hepatotoxicity and steatohepatitis PMID: 26619823
    5. Elongation of Very Long Chain fatty acids 6 (Elovl6) is necessary for the thermogenic action of brown adipose tissue PMID: 26628376
    6. Data (including data from studies in knockout mice) confirm Elovl6 as only enzyme elongating palmitate to oleate; elongation of palmitoleate to vaccinate does not require Elovl6; deletion of Elovl6 does not prevent nonalcoholic fatty liver disease. PMID: 25281760
    7. Our findings suggest that Elovl6 could be involved in insulin secretory capacity per beta-cell and diabetes. PMID: 24938128
    8. Elovl6 deficiency results in a change in fatty acid composition, induction of apoptosis, TGF-beta1 expression and reactive oxygen species generation. PMID: 24113622
    9. Elovl6 is a critical modulator for atherogenic high-fat diet-induced inflammation, oxidative stress, and fibrosis in the liver. PMID: 22753171
    10. REVIEW: fatty acid metabolism and lipotoxicity; discussion of the role of Elovl6 in newly recognized aspects of metabolic regulation PMID: 22266797
    11. Elovl6 in macrophages may contribute to foam cell formation and progression of atherosclerosis. PMID: 21817094
    12. data indicate this elongase is a lipogenic enzyme regulated by SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase. PMID: 12032166
    13. These data demonstrated that Elovl-6 is regulated directly and primarily by SREBP-1c. PMID: 18226595
    14. Change in composition of fatty acids due to Elovl-6 is the dicisive factor for gene expression of energy metabolism and life-style associated disorders. (review) PMID: 18810844
    15. Studies suggest that inhibition of ELOVL6 could be a new therapeutic approach for the treatment of insulin resistance, diabetes, cardiovascular disease, and other metabolic diseases. PMID: 19259639

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ELO family, ELOVL6 subfamily
  • 组织特异性：
    Highly expressed in adrenal gland, liver, white adipose tissue (WAT), adult and fetal brain, cerebellum, spinal cord, testis, skin and peripheral nerve; where lipogenesis and steroidogenesis are active. Weakly expressed in kidney, heart, skeletal muscle,
  • 数据库链接：

    KEGG: mmu:170439

    STRING: 10090.ENSMUSP00000071351

    UniGene: Mm.314113