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  4. Recombinant Mouse DnaJ homolog subfamily C member 15 (Dnajc15)

Recombinant Mouse DnaJ homolog subfamily C member 15 (Dnajc15)

  • 中文名称：
    小鼠Dnajc15重组蛋白
  • 货号：
    CSB-CF762363MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
    Dnajc15
  • Uniprot No.：
  • 别名：
    Dnajc15; Dnajd1; DnaJ homolog subfamily C member 15
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-149
  • 氨基酸序列
    MATGGGVTSREGLRYAEYLPPSAQRSDADIDHTAGRRLLAVGLGVAAVAFAGRYAFQIWK PLEQVITATARKISSPSFSSYYKGGFEQKMSKREASLILGVSPSAGKAKIRTAHKRIMIL NHPDKGGSPYLASKINEAKDLLEASSKAN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP.
  • 基因功能参考文献：
    1. In vivo treatment with an inhibitor of MCJ expression protects liver from acetaminophen-induced liver injury in mouse model at a time when N-acetylcysteine, the standard therapy, has no efficacy. Acetaminophen-induced liver injury progresses through the central participation of MCJ in vitro and in vivo. PMID: 29233977
    2. DNAJC15 localizes at the mitochondrial inner membrane, where it interacts preferentially with complex I of the electron transfer chain.DnaJC15 functions as a negative regulator of mitochondrial membrane potential and ATP production. PMID: 23530063
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 组织特异性：
    Expressed at high levels in liver, heart, at moderate levels in kidney and, at very low levels, in lung (at protein level). High expression levels in testis. Highly expressed in CD8+ T-cells, but barely detectable in CD4+ T-cells (at protein level). Almos
  • 数据库链接：

    KEGG: mmu:66148

    STRING: 10090.ENSMUSP00000022590

    UniGene: Mm.248046