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  4. Recombinant Mouse Desmocollin-3 (Dsc3)

Recombinant Mouse Desmocollin-3 (Dsc3)

In Stock
  • 中文名称：
    小鼠Dsc3重组蛋白
  • 货号：
    CSB-CF007191MO
  • 规格：
    ￥12960
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Dsc3
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    in vitro E.coli expression system
  • 分子量：
    86.3 kDa
  • 表达区域：
    136-896aa
  • 氨基酸序列
    RWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTVFYSISGRGADQEPLNWFFIERDTGNLYCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIKIEDENDNYPLFTEAIYAFEVPEGSRLGTVVGTVCATDKDEPDTMHTRLKYSILEQTPPSPGLFSVHPDTGVITTVSHYMDREVVDKYKLIMKVQDMNGQFFGLISTSTCIITVQDSNDNAPTFRQNTYETAVEENTYNVEILRIPVDDKDMINTANWKANFTILKGNENGWFKITTDPVTNEGVLCVVKPLDYEENRQVTLEIGVNNEAPFIKDVANRIPTMNRAMVTVHVKDQNEGPECKPPEQYVRIKENSAVGSKINGYKAYDPETKNSNGLRYKKLQDPKDWVSIEEVSGLLTISKTLDREIMAPRNDMYNITVMAIDQEGKSCTGTLAVNIEDVNDNAPEIIQDYIVICKPKMGYTDISAVDPDEPIHGPPFQFNLANTSPEVNRIWTLNQVNDTAARLSYQKTADVQIYNVPVTVKDRAGQSATKILRVNLCDCTHPSQCPLRSRSAGITLGKWAILAILLGIALLFSVLLTLVCGVVTARKGKHFPEDLAQQNLIISNTEAPGDDRVCSANGFTTHTANNSSQGFCGTMGSGMRNGGQETIEMMKGHQTLDSCRVAGHHHTLDSGRGGHMDTDNCRYTYSEWHSFTQPRLGEKLHVCNQNEDHIPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEEGLDFLNNLEPKFLTLAETCTKR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
  • 基因功能参考文献：
    1. hypothesize that DSC3 can contribute to the progression of tumors both by cell adhesion-dependent (skin surface) and likely by cell adhesion-independent (invading tumor cells) mechanisms PMID: 21681825
    2. The function of DSC3 in the development and maintenance of stratified epithelia, in particular the epidermis and hair follicles, was investigated. PMID: 18682494
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
  • 组织特异性：
    First expressed at E13.0 in epithelium of whisker pads and external nares, and in most mature vibrissa follicles. 12 hours later, prominently expressed in whiskers and tactile follicles above the eye. At E14.5, also expressed in developing nails and teeth
  • 数据库链接：

    KEGG: mmu:13507

    STRING: 10090.ENSMUSP00000111514

    UniGene: Mm.89935